Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization.

Autor: Han KA; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu, 42988, Korea.; Center for Synapse Diversity and Specificity, DGIST, Daegu, 42988, Korea., Ko J; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333 Techno Jungangdae-Ro, Hyeonpoong-Eup, Dalseong-Gun, Daegu, 42988, Korea. jaewonko@dgist.ac.kr.; Center for Synapse Diversity and Specificity, DGIST, Daegu, 42988, Korea. jaewonko@dgist.ac.kr.
Jazyk: angličtina
Zdroj: Experimental & molecular medicine [Exp Mol Med] 2023 Jun; Vol. 55 (6), pp. 1065-1075. Date of Electronic Publication: 2023 Jun 01.
DOI: 10.1038/s12276-023-01004-1
Abstrakt: The WAVE regulatory complex (WRC), composed of five components-Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300-is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.
(© 2023. The Author(s).)
Databáze: MEDLINE
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