The core outcomes for open lower limb fracture study.

Autor:	Aquilina AL; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; Musculoskeletal Research Unit, Translational Health Sciences, University of Bristol, Bristol, UK., Claireaux H; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Aquilina CO; The Royal Free Hospital NHS Foundation Trust, London, UK., Tutton E; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Fitzpatrick R; University of Oxford Nuffield Department of Population Health, Oxford, UK., Costa ML; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Griffin XL; Barts Health NHS Trust, London, UK.; Bone and Joint Health, Blizard Institute, Queen Mary University of London, London, UK.
Jazyk:	angličtina
Zdroj:	Bone & joint research [Bone Joint Res] 2023 Jun 01; Vol. 12 (6), pp. 352-361. Date of Electronic Publication: 2023 Jun 01.
DOI:	10.1302/2046-3758.126.BJR-2022-0280.R1
Abstrakt:	Aims: A core outcome set for adult, open lower limb fracture has been established consisting of 'Walking, gait and mobility', 'Being able to return to life roles', 'Pain or discomfort', and 'Quality of life'. This study aims to identify which outcome measurement instruments (OMIs) should be recommended to measure each core outcome. Methods: A systematic review and quality assessment were conducted to identify existing instruments with evidence of good measurement properties in the open lower limb fracture population for each core outcome. Additionally, shortlisting criteria were developed to identify suitable instruments not validated in the target population. Candidate instruments were presented, discussed, and voted on at a consensus meeting of key stakeholders. Results: The Wales Lower Limb Trauma Recovery scale was identified, demonstrating validation evidence in the target population. In addition, ten candidate OMIs met the shortlisting criteria. Six patients, eight healthcare professionals, and 11 research methodologists attended the consensus meeting. Consensus was achieved for the EuroQol five-dimension five-level questionnaire (EQ-5D-5L) and the Lower Extremity Functional Scale (LEFS) to measure 'Quality of life' and 'Walking, gait and mobility' in future research trials, audit, and clinical assessment, respectively. No instrument met consensus criteria to measure 'Being able to return to life roles' and 'Pain or discomfort'. However, the EQ-5D-5L was found to demonstrate good face validity and could also be used pragmatically to measure these two outcomes, accepting limitations in sensitivity. Conclusion: This study recommends the LEFS and EQ-5D-5L to measure the core outcome set for adult open lower limb fracture. Competing Interests: X. L. Griffin reports institutional grants (paid to Queen Mary University of London) from the National Institute for Health and Care Research, not related to this study. (© 2023 Author(s) et al.)
Databáze:	MEDLINE
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