Topiramate treatment during the peripubertal period does not alter aortic endothelial function in female Wistar rats.

Autor: Silva DGD; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil; Graduation Program of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil., Moura KF; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil; Graduation Program of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil., Souza AC; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil., Silva KGND; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil; Graduation Program of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil., Vidigal CB; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil., da Silva Jezuíno J; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil., Gravena RC; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil., Pelosi GG; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil; Graduation Program of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil., Gerardin DCC; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil; Graduation Program of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil., do Carmo Franco M; Department of Physiology, Federal University of São Paulo, São Paulo, Brazil., Ceravolo GS; Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil; Graduation Program of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, PR, Brazil. Electronic address: gsceravolo@uel.br.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2023 Aug 15; Vol. 327, pp. 121819. Date of Electronic Publication: 2023 May 29.
DOI: 10.1016/j.lfs.2023.121819
Abstrakt: Aims: This study aimed to evaluate the short- and long-term adverse effects of blood pressure (BP), vascular endothelial function, and estrogen receptor (ERα and ERβ) modulation on endothelial function in female Wistar rats treated with topiramate (TPM), an antiepileptic drug, during the peripubertal period.
Materials and Methods: Female Wistar rats were treated with TPM (41 mg/kg) or water (CTR group) by gavage from postnatal day (PND) 28 to 50 (peripubertal phase). At the end of the treatment, the TPM and CTR rats were divided into two groups and evaluated after 24 h or from PND 85 (adulthood). The rats were evaluated for: thoracic aorta reactivity to phenylephrine (Phenyl), acetylcholine (ACh), and sodium nitroprusside (SNP); aortic ring reactivity after ERα and ERβ antagonism; and BP.
Key Findings: It was observed that vascular response to Phenyl, ACh, and SNP was similar between TPM and CTR rats in the short- and long-term evaluations. In addition, the ER antagonism did not interfere with aortic contraction or relaxation in either TPM or CTR.
Significance: Taken together, the results show that TPM treatment during the peripubertal period does not alter aortic endothelial function and its estrogen modulation via classic ER in female Wistar rats, suggesting that TPM treatment in this period is safe for the vascular system.
Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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