The antioxidant effect of Aronia melanocarpa extract in rats oxidative stress induced by cisplatin administration.

Autor: Doma AO; University of Life Sciences' King Michael I' from Timisoara, Faculty of Veterinary Medicine, Romania., Cristina RT; University of Life Sciences' King Michael I' from Timisoara, Faculty of Veterinary Medicine, Romania., Dumitrescu E; University of Life Sciences' King Michael I' from Timisoara, Faculty of Veterinary Medicine, Romania., Degi D; University of Life Sciences' King Michael I' from Timisoara, Faculty of Veterinary Medicine, Romania., Moruzi RF; University of Life Sciences' King Michael I' from Timisoara, Faculty of Veterinary Medicine, Romania., Brezovan D; University of Life Sciences' King Michael I' from Timisoara, Faculty of Veterinary Medicine, Romania., Petroman I; University of Life Sciences' King Michael I' from Timisoara, Faculty of Agricultural Management, Romania., Muselin F; University of Life Sciences' King Michael I' from Timisoara, Faculty of Veterinary Medicine, Romania; Working Group for Xenobiochemistry, Romanian Academy-Branch Timisoara, Romania. Electronic address: florinmuselin@usab-tm.ro.
Jazyk: angličtina
Zdroj: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2023 Sep; Vol. 79, pp. 127205. Date of Electronic Publication: 2023 May 18.
DOI: 10.1016/j.jtemb.2023.127205
Abstrakt: Background: The reactive oxygen species generated by numerous xenobiotic substances has as consequences the impairment of different organs normal function. Many plants pose antioxidant activity to counteract oxidative stress, among them being the chokeberry (Aronia melanocarpa). The purpose of present study was to determine if the use of A. melanocarpa extract can counteract the oxidative stress induced by cisplatin administration in rats.
Material and Methods: The study was made on forty Wistar rats divided in four groups as follows: C (control): receiving i.p. 1 mL of saline solution; E1: receiving cisplatin 20 mg/kg bw, i.p.; E2: receiving cisplatin 20 mg/kg bw, i.p and A. melanocarpa berry 6 % aqueous extract as drinking water, and CB (control blank): i.p 1 mL saline solution and A. melanocarpa 6 % aqueous extract for four weeks.
Results: Administration of Cisplatin was followed by the increase of serum superoxide dismutase (+21.18 %, P < 0.05), catalase (+25.44 %, P < 0.001), glutathione peroxidase (+17.88 %, P < 0.05) and thiobarbituric reactive substances (+28.17 %, P < 0.01) but significantly decreased glutathione reductase (-22.35 %, P < 0.001) level comparative to control, pointing out that administration of cisplatin induced oxidative stress in rats. In groups that received A. melanocarpa extract as drinking water, we noted that the levels of the oxidative stress biomarkers tended to be restored almost to normal levels, which could be a possible good antioxidant used in condition to cisplatin use. Also, we noted a significant (P < 0.001) decrease of total antioxidant capacity in liver and kidney of rats exposed to cisplatin, recovered in those that received chokeberry. Studied trace elements important for the stress oxidative enzymes (Cu, Zn, Fe and Mn) were decreased in cisplatin exposed groups compared to control and mainly all were almost to normal level in groups receiving A. melanocarpa.
Conclusion: A. melanocarpa extract due to its antioxidants content could offer protection against free radicals produced as a consequence of cisplatin use.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved.)
Databáze: MEDLINE
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