Area Deprivation Index in Patients with Invasive Lobular Carcinoma of the Breast: Associations with Tumor Characteristics and Outcomes.

Autor:	Kaur M; School of Medicine, University of California, San Francisco, California., Patterson A; Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, California., Molina-Vega J; Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, California., Rothschild H; School of Medicine, University of California, San Francisco, California., Clelland E; School of Medicine, University of California, San Francisco, California., Ewing CA; Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, California., Mujir F; Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, California., Esserman LJ; Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, California., Olopade OI; Hematology/Oncology Section, University of Chicago, Chicago, Illinois., Mukhtar RA; Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, California.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2023 Aug 01; Vol. 32 (8), pp. 1107-1113.
DOI:	10.1158/1055-9965.EPI-22-1353
Abstrakt:	Background: Although investigators have shown associations between socioeconomic status (SES) and outcomes in breast cancer, there is a paucity of such data for invasive lobular carcinoma (ILC), the second most common type of breast cancer. Herein we evaluated the relationship between SES with tumor features and outcomes in stage I to III patients with ILC. Methods: We analyzed a prospectively maintained institutional ILC database and utilized the area deprivation index (ADI) to determine neighborhood adversity, an indicator of SES. We used Cox proportional hazards models in Stata 17.0 to evaluate relationships between ADI quintile (Q), race, body mass index (BMI), clinicopathologic features, treatment type, and event-free survival (EFS). Results: Of 804 patients with ILC, 21.4% lived in neighborhoods classified as ADI Q1 (least resource-deprived) and 19.7% in Q5 (most resource-deprived). Higher deprivation was significantly associated with larger tumor size (3.6 cm in Q5 vs. 3.1 cm in Q1), increased presence of lymphovascular invasion (8.9% in Q5 vs. 6.7% in Q1), and decreased use of adjuvant endocrine therapy (67.1% in Q5 vs. 73.6% in Q1). On multivariable analysis, tumor size, receptor subtypes, and omission of adjuvant endocrine therapy were associated with reduced EFS. Conclusions: These data show that patients with ILC and higher ADI experience more aggressive tumors and differences in treatment. More data evaluating the complex relationships between these factors is needed to optimize outcomes for patients with ILC, regardless of SES. Impact: ADI is associated with differences in patients with ILC. (©2023 The Authors; Published by the American Association for Cancer Research.)
Databáze:	MEDLINE
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