Exercise and epigenetic ages in older adults with myeloid malignancies.

Autor: Loh KP; James P. Wilmot Cancer Institute, Rochester, NY, USA. kahpoh_loh@urmc.rochester.edu.; Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY, 14642, USA. kahpoh_loh@urmc.rochester.edu., Sanapala C; James P. Wilmot Cancer Institute, Rochester, NY, USA., Jensen-Battaglia M; Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA., Rana A; School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA., Sohn MB; Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA., Watson E; Department of Psychology, Princeton University, Princeton, NJ, USA., Gilmore N; Division of Cancer Control, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA., Klepin HD; Wake Forest Baptist Comprehensive Cancer Center, Medical Center Blvd, Winston-Salem, NC, USA., Mendler JH; James P. Wilmot Cancer Institute, Rochester, NY, USA.; Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY, 14642, USA., Liesveld J; James P. Wilmot Cancer Institute, Rochester, NY, USA.; Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY, 14642, USA., Huselton E; James P. Wilmot Cancer Institute, Rochester, NY, USA.; Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY, 14642, USA., LoCastro M; James P. Wilmot Cancer Institute, Rochester, NY, USA.; School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA., Susiarjo M; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA., Netherby-Winslow C; Division of Cancer Control, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA., Williams AM; Division of Cancer Control, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA., Mustian K; James P. Wilmot Cancer Institute, Rochester, NY, USA.; Division of Cancer Control, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA., Vertino P; James P. Wilmot Cancer Institute, Rochester, NY, USA.; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA., Janelsins MC; James P. Wilmot Cancer Institute, Rochester, NY, USA.; Division of Cancer Control, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Jazyk: angličtina
Zdroj: European journal of medical research [Eur J Med Res] 2023 May 30; Vol. 28 (1), pp. 180. Date of Electronic Publication: 2023 May 30.
DOI: 10.1186/s40001-023-01145-z
Abstrakt: Background: Older adults with myeloid malignancies are susceptible to treatment-related toxicities. Accelerated DNAm age, or the difference between DNA methylation (DNAm) age and chronological age, may be used as a biomarker of biological age to predict individuals at risk. In addition, cancer treatment can also lead to accelerated DNAm age. Exercise is a promising intervention to reduce or prevent functional, psychological, and cognitive impairments in older patients with myeloid malignancies, yet there is little evidence of the effects of exercise on DNAm age. We explored (1) the associations of accelerated DNAm age with physical, psychological, and cognitive functions at baseline; (2) changes in DNAm age from baseline to post-intervention; and (3) the associations of changes in accelerated DNAm age with changes in functions from baseline to post-intervention.
Methods: We enrolled older patients with myeloid malignancies to a single-arm pilot study testing a mobile health (mHealth) exercise intervention that combines an exercise program (EXCAP ©® ) with a mobile application over 2 cycles of chemotherapy (8-12 weeks). Patients completed measures of physical, psychological, and cognitive functions and provided blood samples for analyses of DNAm age at baseline and post-intervention. Paired t-tests or Wilcoxon signed rank tests assessed changes in DNAm ages, and Spearman's correlation assessed the relationships between accelerated ages and functions.
Results: We included 20 patients (mean age: 72 years, range 62-80). Accelerated GrimAge, accelerated PhenoAge, and DunedinPACE were stable from baseline to post-intervention. At baseline, DunedinPACE was correlated with worse grip strength (r = -0.41, p = 0.08). From baseline to post-intervention, decreases in accelerated GrimAge (r = -0.50, p = 0.02), accelerated PhenoAge (r = - 0.39, p = 0.09), and DunedinPace (r = - 0.43, p = 0.06) were correlated with increases in distance walked on 6-min walk test. Decreases in accelerated GrimAge (r = - 0.49, p = 0.03), accelerated PhenoAge (r = - 0.40, p = 0.08), and DunedinPace (r = - 0.41, p = 0.07) were correlated with increases in in grip strength.
Conclusions: Among older adults with myeloid malignancies receiving chemotherapy, GrimAge and PhenoAge on average are stable after a mHealth exercise intervention. Decreases in accelerated GrimAge, accelerated PhenoAge, and DunedinPACE over 8-12 weeks of exercise were correlated with increased physical performance. Future trials assessing the effects of exercise on treatment-related toxicities should evaluate DNAm age. Trial registration Clinicaltrials.gov identifier: NCT04981821.
(© 2023. The Author(s).)
Databáze: MEDLINE
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