Strawberry Additive Increases Nicotine Vapor Sampling and Systemic Exposure But Does Not Enhance Pavlovian-Based Nicotine Reward in Mice.

Autor:	Patten T; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104.; Pharmacology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104., Johnson NL; Department of Pharmacology and Therapeutics, Center for Smell and Taste, Center for Addiction Research and Education, University of Florida College of Medicine, Gainesville, Florida 32610., Shaw JK; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104., Dossat AM; Department of Pharmacology and Therapeutics, Center for Smell and Taste, Center for Addiction Research and Education, University of Florida College of Medicine, Gainesville, Florida 32610., Dreier A; School of Arts and Sciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104., Kimball BA; Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104., Wesson DW; Department of Pharmacology and Therapeutics, Center for Smell and Taste, Center for Addiction Research and Education, University of Florida College of Medicine, Gainesville, Florida 32610., De Biasi M; Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 marielde@pennmedicine.upenn.edu.; Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104.; Pharmacology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104.; School of Arts and Sciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Jazyk:	angličtina
Zdroj:	ENeuro [eNeuro] 2023 Jun 13; Vol. 10 (6). Date of Electronic Publication: 2023 Jun 13 (Print Publication: 2023).
DOI:	10.1523/ENEURO.0390-22.2023
Abstrakt:	Nicotine is an addictive drug whose popularity has recently increased, particularly among adolescents, because of the availability of electronic nicotine devices (i.e., "vaping") and nicotine e-liquids containing additives with rich chemosensory properties. Some efforts to understand the role of these additives in nicotine reward suggest that they increase nicotine reward and reinforcement, but the sensory contributions of additives, especially in their vapor forms, are largely untested. Here, to better understand how a fruit-flavored (i.e., strawberry) additive influences nicotine reward and aversion, we used a conditioned place preference (CPP) procedure in which nicotine and a strawberry additive were delivered as a vapor to male and female adolescent mice. We found that nicotine vapor alone can lead to a dose-dependent CPP when using a biased design. The strawberry additive did not produce CPP on its own, and we did not observe an effect of the strawberry additive on nicotine vapor-induced reward. Nevertheless, mice exposed to nicotine plus strawberry additive vapor had higher plasma cotinine concentrations, which did not appear to reflect altered nicotine metabolism. Instead, by directly measuring vapor sampling through respiration monitoring, we uncovered an increase in the amount of sniffing toward strawberry-containing nicotine vapor compared with nicotine vapor alone. Together these data indicate that chemosensory-rich e-liquid additives may enhance the perceived sensory profile of nicotine vapors rather than the reward value per se, which leads to overall increased nicotine exposure. Competing Interests: The authors declare no competing financial interests. (Copyright © 2023 Patten et al.)
Databáze:	MEDLINE
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