Host-pathogen interactions mediated by extracellular vesicles in Toxoplasma gondii infection during pregnancy.

Autor: Gómez-Chávez F; Sección de Estudios de Posgrado e Investigación, Escuela Nacional de Medicina y Homeopatía-Instituto Politécnico Nacional, Mexico City, Mexico; Programa de Posgrado en Ciencia y Tecnología de Vacunas y Bioterapéuticos, Instituto Politécnico Nacional, Mexico City, Mexico., Murrieta-Coxca JM; Placenta Lab, Department of Obstetrics, Jena University Hospital, Jena, Germany., Caballero-Ortega H; Secretaría de Salud, Laboratorio de Inmunología Experimental, Instituto Nacional de Pediatría, Mexico City, Mexico., Morales-Prieto DM; Placenta Lab, Department of Obstetrics, Jena University Hospital, Jena, Germany., Markert UR; Placenta Lab, Department of Obstetrics, Jena University Hospital, Jena, Germany. Electronic address: udo.markert@med.uni-jena.de.
Jazyk: angličtina
Zdroj: Journal of reproductive immunology [J Reprod Immunol] 2023 Aug; Vol. 158, pp. 103957. Date of Electronic Publication: 2023 May 18.
DOI: 10.1016/j.jri.2023.103957
Abstrakt: Molecular communication between a pathogen and its host is crucial for a successful interplay. Extracellular vesicles (EVs) act as mediators for the delivery of molecular signals among pathogens or between pathogens and the host. Toxoplasma gondii (T. gondii), an intracellular parasite with a worldwide presence, produces EVs itself, or induces the secretion of EVs from infected host cells potentially having capacities to modulate the host immune response. T. gondii infection is particularly important during pregnancy. Depending on the gestational age at the time of infection, the parasite can be transmitted through the placenta to the fetus, causing clinical complications such as jaundice, hepatosplenomegaly, chorioretinitis, cranioencephalic abnormalities, or even death. T. gondii infection is related to a pro-inflammatory immune response in both mother and fetus, which may enhance parasite transmission, but the implication of EV signaling in this process remains unclear. In this review, we summarize the current knowledge on EV release from T. gondii and its human host cells in regard to the immunological consequences and the passage through the placenta.
Competing Interests: Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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