Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions.

Autor:	Navarro Lobato I; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands., Aleman-Zapata A; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands., Samanta A; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands., Bogers M; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands., Narayanan S; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands., Rayan A; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands., Alonso A; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands., van der Meij J; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands., Khamassi M; Institute of Intelligent Systems and Robotics, CNRS, Sorbonne Université, Paris, France., Khan ZU; Laboratory of Neurobiology, CIMES, University of Malaga, Malaga, Spain., Genzel L; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2023 May 30; Vol. 12. Date of Electronic Publication: 2023 May 30.
DOI:	10.7554/eLife.84911
Abstrakt:	Our brain is continuously challenged by daily experiences. Thus, how to avoid systematic erasing of previously encoded memories? While it has been proposed that a dual-learning system with 'slow' learning in the cortex and 'fast' learning in the hippocampus could protect previous knowledge from interference, this has never been observed in the living organism. Here, we report that increasing plasticity via the viral-induced overexpression of RGS14414 in the prelimbic cortex leads to better one-trial memory, but that this comes at the price of increased interference in semantic-like memory. Indeed, electrophysiological recordings showed that this manipulation also resulted in shorter NonREM-sleep bouts, smaller delta-waves and decreased neuronal firing rates. In contrast, hippocampal-cortical interactions in form of theta coherence during wake and REM-sleep as well as oscillatory coupling during NonREM-sleep were enhanced. Thus, we provide the first experimental evidence for the long-standing and unproven fundamental idea that high thresholds for plasticity in the cortex protect preexisting memories and modulating these thresholds affects both memory encoding and consolidation mechanisms. Competing Interests: IN, AA, AS, MB, SN, AR, AA, Jv, MK, ZK, LG No competing interests declared (© 2023, Navarro Lobato et al.)
Databáze:	MEDLINE
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