Maternal prepregnancy obesity and gestational diabetes influence on adverse perinatal outcomes.

Autor:	de Carvalho LS; Programa de Mestrado em Saúde e Meio Ambiente, Universidade da Região de Joinville (Univille), Joinville, SC, Brasil, leocarvalho.sc@gmail.com., de Oliveira AAD; Programa de Mestrado em Saúde e Meio Ambiente, Universidade da Região de Joinville (Univille), Joinville, SC, Brasil., Grabovski TCM; Programa de Mestrado em Saúde e Meio Ambiente, Universidade da Região de Joinville (Univille), Joinville, SC, Brasil., Renzo CC; Programa de Mestrado em Saúde e Meio Ambiente, Universidade da Região de Joinville (Univille), Joinville, SC, Brasil., Ribeiro E Silva R; Faculdade de Medicina, Universidade da Região de Joinville (Univille), Joinville, SC, Brasil., Loz SH; Faculdade de Medicina, Universidade da Região de Joinville (Univille), Joinville, SC, Brasil., Silva JC; Programa de Mestrado em Saúde e Meio Ambiente, Universidade da Região de Joinville (Univille), Joinville, SC, Brasil.; Faculdade de Medicina, Universidade da Região de Joinville (Univille), Joinville, SC, Brasil.; Maternidade Darcy Vargas, Joinville, SC, Brasil.
Jazyk:	angličtina
Zdroj:	Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2023 May 12; Vol. 67 (4), pp. e000605.
DOI:	10.20945/2359-3997000000605
Abstrakt:	Objective: Evaluate the influence of isolated and associated prepregnancy obesity and gestational diabetes mellitus (GDM) on adverse perinatal outcomes. Materials and Methods: Cross-sectional observational study with women who delivered at a Brazilian Maternity Hospital, between August and December 2020. Data were collected by interview with application form, and medical records. Sample was stratified by body mass index (BMI) and GDM screening in four groups: no obesity (BMI < 30 kg/m 2 ) no GDM - reference; isolated GDM; isolated obesity (BMI ≥ 30 kg/m 2 ); and obesity with GDM. Preeclampsia (PE), cesarean section (CS), large-for-gestational-age (LGA) newborn and admission to neonatal intensive care unit (NICU) were analyzed by odds ratio (OR) adjusted for confounding factors, adopting 95% confidence interval (CI) and P < 0.05 statistically significant. Results: From 1,618 participants, isolated obesity group (233/14.40%) had high chance of PE (OR = 2.16; CI: 1.364-3.426; P = 0.001), isolated GDM group (190/11.74%) had high chance of CS (OR = 1.736; CI: 1.136-2.652; P = 0.011) and NICU admission (OR = 2.32; CI: 1.265-4.261; P = 0.007), and obesity with GDM group (121/7.48%) had high chance of PE (OR = 1.93; CI: 1.074-3.484; P = 0.028), CS (OR = 1.925; CI: 1.124-3.298; P = 0.017) and LGA newborn (OR = 1.81; CI: 1.027-3.204; P = 0.040), compared with reference (1,074/66.38%). Conclusion: Obesity and GDM enhances the chance of different negative outcomes, worsening this prognosis when associated.
Databáze:	MEDLINE
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