Oxazolidinones as versatile scaffolds in medicinal chemistry.
| Autor: | Fernandes GFS; Department of Chemistry, University College London 20 Gordon Street WC1H 0AJ London UK guilherme.fernandes@ucl.ac.uk d.castagnolo@ucl.ac.uk., Scarim CB; Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University Araraquara 14800903 Brazil., Kim SH; Department of Chemistry, University College London 20 Gordon Street WC1H 0AJ London UK guilherme.fernandes@ucl.ac.uk d.castagnolo@ucl.ac.uk.; School of Cancer and Pharmaceutical Sciences, King's College London 150 Stamford Street SE1 9NH London UK., Wu J; Department of Chemistry, University College London 20 Gordon Street WC1H 0AJ London UK guilherme.fernandes@ucl.ac.uk d.castagnolo@ucl.ac.uk., Castagnolo D; Department of Chemistry, University College London 20 Gordon Street WC1H 0AJ London UK guilherme.fernandes@ucl.ac.uk d.castagnolo@ucl.ac.uk. |
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| Jazyk: | angličtina |
| Zdroj: | RSC medicinal chemistry [RSC Med Chem] 2023 Feb 08; Vol. 14 (5), pp. 823-847. Date of Electronic Publication: 2023 Feb 08 (Print Publication: 2023). |
| DOI: | 10.1039/d2md00415a |
| Abstrakt: | Oxazolidinone is a five-member heterocyclic ring with several biological applications in medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most investigated in drug discovery. Linezolid was pioneered as the first approved drug containing an oxazolidinone ring as the pharmacophore group. Numerous analogues have been developed since its arrival on the market in 2000. Some have succeeded in reaching the advanced stages of clinical studies. However, most oxazolidinone derivatives reported in recent decades have not reached the initial stages of drug development, despite their promising pharmacological applications in a variety of therapeutic areas, including antibacterial, antituberculosis, anticancer, anti-inflammatory, neurologic, and metabolic diseases, among other areas. Therefore, this review article aims to compile the efforts of medicinal chemists who have explored this scaffold over the past decades and highlight the potential of the class for medicinal chemistry. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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