Effects of Mitral Valve Prolapse on Heart Rate Variability and the Autonomic Nervous System in Children.

Autor:	Ahmadi M; Student Research Committee, Arak University of Medical Sciences, Arak, Iran., Ghahremani B; Student Research Committee, Arak University of Medical Sciences, Arak, Iran., Habibi D; Department of Biostatistics and Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran., Sadrnia S; Department of Cardiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran., Ghandi Y; Clinical Research Development Center of Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran.
Jazyk:	angličtina
Zdroj:	The journal of Tehran Heart Center [J Tehran Heart Cent] 2022 Jul; Vol. 17 (3), pp. 140-146.
DOI:	10.18502/jthc.v17i3.10847
Abstrakt:	Background: Patients with mitral valve prolapse (MVP) may reveal symptoms of autonomic dysfunction and heart rate variability (HRV). We sought to explore the autonomic nervous system in children with MVP. Methods: This cross-sectional study enrolled 60 children aged between 5 and 15 years with MVP and 60 age- and sex-matched healthy children as controls. Two cardiologists performed electrocardiography and standard echocardiography. HRV parameters were explored via 24-hour rhythm 3-channel Holter monitoring. The depolarization of ventricular and atrial parameters, comprising QT max and min, QTc intervals, QT dispersion, P maximum and minimum, and P-wave dispersion, was measured and compared. Results: The mean age was 13.12±1.50 years in the MVP group (F/M: 34/26) and 13.20±1.81 years in the control group (F/M: 35/25). The maximum duration and P-wave dispersion in the MVP group were significantly different from the healthy children (P<0.001). The longest and shortest QT dispersion values and QTc values were significantly different between the 2 groups (P=0.004, P=0.043, P<0.001, and P<0.001, respectively). The HRV parameters were significantly different between the 2 groups, too. Conclusion: Decreased HRV and inhomogeneous depolarization showed that our children with MVP were prone to atrial and ventricular arrhythmias. Furthermore, P-wave dispersion and QTc could be used as prognostic markers of cardiac autonomic dysfunction before it is diagnosed by 24-hour Holter monitoring. (Copyright © 2022 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.)
Databáze:	MEDLINE
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