Biomarkers of delirium risk in older adults: a systematic review and meta-analysis.

Autor:	Lozano-Vicario L; Geriatric Unit, Hospital Universitario de Navarra (HUN), Pamplona, Spain., García-Hermoso A; Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain., Cedeno-Veloz BA; Geriatric Unit, Hospital Universitario de Navarra (HUN), Pamplona, Spain., Fernández-Irigoyen J; Proteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IDISNA), Pamplona, Spain., Santamaría E; Proteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IDISNA), Pamplona, Spain., Romero-Ortuno R; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland., Zambom-Ferraresi F; Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.; CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain., Sáez de Asteasu ML; Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain., Muñoz-Vázquez ÁJ; Orthopaedic Surgery and Traumatology Department, Clínica Universidad de Navarra, Pamplona, Spain., Izquierdo M; Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.; CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain., Martínez-Velilla N; Geriatric Unit, Hospital Universitario de Navarra (HUN), Pamplona, Spain.; Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.; CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2023 May 12; Vol. 15, pp. 1174644. Date of Electronic Publication: 2023 May 12 (Print Publication: 2023).
DOI:	10.3389/fnagi.2023.1174644
Abstrakt:	Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two authors independently and systematically searched MEDLINE, Embase, Cochrane Library, Web of Science and Scopus databases up to August 2021. A total of 32 studies were included. Only 6 studies were eligible for the meta-analysis, pooled results showed a significant increase in some serum biomarkers (C-reactive protein [CRP], tumour necrosis factor alpha [TNF-α] and interleukin-6 [IL-6]) among patients with delirium (odds ratio = 1.88, 95% CI 1.01 to 1.637; I2 = 76.75%). Although current evidence does not favour the use of any particular biomarker, serum CRP, TNF- α , and IL-6 were the most consistent biomarkers of delirium in older patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Lozano-Vicario, García-Hermoso, Cedeno-Veloz, Fernández-Irigoyen, Santamaría, Romero-Ortuno, Zambom-Ferraresi, Sáez de Asteasu, Muñoz-Vázquez, Izquierdo and Martínez-Velilla.)
Databáze:	MEDLINE
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