Creutzfeldt-Jakob disease in a post-COVID-19 patient: did SARS-CoV-2 accelerate the neurodegeneration?

Autor: Alloush TK; Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Alloush AT; Department of Geriatrics and Gerontology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Abdelazeem Y; Departement of Diagnostic Radiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Shokri HM; Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Abdulghani KO; Department of Neurology and Psychiatry, Helwan University School of Medicine, Cairo, Egypt., Elzoghby A; Departement of Diagnostic Radiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: The Egyptian journal of neurology, psychiatry and neurosurgery [Egypt J Neurol Psychiatr Neurosurg] 2023; Vol. 59 (1), pp. 69. Date of Electronic Publication: 2023 May 22.
DOI: 10.1186/s41983-023-00666-y
Abstrakt: Background: Creutzfeldt-Jakob disease (CJD) is a rare, fatal neurodegenerative disorder, with few months as a usual duration from onset to death.
Case Presentation: In this case report, a patient of Sporadic CJD (sCJD) who presented one month after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The diagnosis of this case was established after confirming findings from clinical, neurophysiology, radiological, and laboratory features of this disease.
Conclusion: Putting in mind all the updated data on the pathogenesis of CJD and the immune responses to SARS-CoV-2, we can suggest that COVID-19 can lead to accelerated pathogenesis and exaggerated manifestations of this fatal neurodegenerative disease.
Competing Interests: Competing interestsThe authors declare that they have no competing interests.
(© The Author(s) 2023.)
Databáze: MEDLINE
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