A Retrospective, Multicenter, Observational Study to Evaluate Clinical Outcomes of Lorlatinib After Alectinib in Patients With ALK -Positive NSCLC in Japan.

Autor:	Goto Y; National Cancer Center Hospital, Tokyo, Japan., Kenmotsu H; Shizuoka Cancer Center, Shizuoka, Japan., Tamiya M; Osaka International Cancer Institute, Osaka, Japan., Murakami S; Kanagawa Cancer Center, Kanagawa, Japan., Kurata T; Kansai Medical University Hospital, Osaka, Japan., Yanagitani N; Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan., Taniguchi H; Toyama Central Hospital, Toyama, Japan., Kuyama S; Iwakuni Clinical Center, Yamaguchi, Japan., Shimizu J; Aichi Cancer Center Hospital, Aichi, Japan., Yokoyama T; Kurashiki Central Hospital, Okayama, Japan., Shimada N; Juntendo University, Tokyo, Japan., Maeda T; Yamaguchi Ube Medical Center, Yamaguchi, Japan., Tamiya A; Kinki-Chuo Chest Medical Center, Osaka, Japan., Uchiyama A; Jichi Medical University, Tochigi, Japan., Imaizumi K; Fujita Health University, Aichi, Japan., Takahama T; Kindai University, Osaka, Japan., Kato T; Kanagawa Cancer Center, Kanagawa, Japan., Hayashi H; Kindai University, Osaka, Japan., Shiraiwa N; Pfizer Japan, Tokyo, Japan., Toyoizumi S; Pfizer R&D, Tokyo, Japan., Kikkawa H; Pfizer Japan, Tokyo, Japan., Thomaidou D; Pfizer Inc., Athens, Greece., Nishio M; Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	JTO clinical and research reports [JTO Clin Res Rep] 2023 Mar 24; Vol. 4 (5), pp. 100508. Date of Electronic Publication: 2023 Mar 24 (Print Publication: 2023).
DOI:	10.1016/j.jtocrr.2023.100508
Abstrakt:	Introduction: Lorlatinib is an ALK tyrosine kinase inhibitor approved in Japan for the treatment of advanced ALK + NSCLC. There has been little evidence about lorlatinib efficacy after first-line (1L) alectinib in clinical practice in Japan. Methods: We retrospectively analyzed patients with advanced ALK + NSCLC previously treated with 1L alectinib at multiple sites in Japan. Primary objectives were to collect patient demographics at baseline and estimate time to treatment failure (TTF) with second-line (2L) or third-line (3L) or later line (≥3L) lorlatinib treatment. Secondary objectives included objective response rate (ORR) with lorlatinib, reason for discontinuation and time to last treatment failure with lorlatinib, TTF and ORR of alectinib, and combined TTF. Results: Among the 51 patients included in the study, 29 (56.9%) received 2L and 22 (43.1%) received ≥3L lorlatinib treatment. At lorlatinib initiation, brain metastases were reported in 25 patients (49.0%), and 32 (62.7%) had an Eastern Cooperative Oncology Group performance status of 0 or 1. Median TTF with lorlatinib was 11.1 months (95% confidence interval [CI]: 4.6-13.8) in any line, 10.8 months (95% CI: 3.9-13.8) in 2L, and 11.5 months (95% CI: 2.9-not reached) in ≥3L. Median TTF was 11.5 months (95% CI: 3.9-not reached) in patients with brain metastases at lorlatinib initiation and 9.9 months (95% CI: 4.3-13.8) in patients without brain metastases. ORR was 35.7% with any-line lorlatinib treatment. Conclusions: Patient characteristics and efficacy were comparable with previous reports when lorlatinib was given after 1L alectinib in patients with ALK + NSCLC. (© 2023 The Authors.)
Databáze:	MEDLINE
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