Synthesis and Exfoliation of Calcium Organophosphonates for Tailoring Rheological Properties of Sodium Alginate Solutions: A Path toward Polysaccharide-Based Bioink.

Autor:	Kopecká K; SYNPO, a.s., S. K. Neumanna 1316, 532 07 Pardubice, Czech Republic.; Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 53210 Pardubice, Czech Republic.; Joint Laboratory of Solid State Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentska 84, 53210 Pardubice, Czech Republic., Vítková L; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 76001 Zlin, Czech Republic., Kroneková Z; Polymer Institute of Slovak academy of Sciences, Dubravska cesta 9, 84541 Bratislava, Slovak Republic.; National Institute of Rheumatic Diseases, Nabrezie I. Krasku 4, 921 12 Piestany, Slovak Republic., Musilová L; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 76001 Zlin, Czech Republic.; Centre of Polymer Systems, Tomas Bata University in Zlin, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic., Smolka P; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 76001 Zlin, Czech Republic.; Centre of Polymer Systems, Tomas Bata University in Zlin, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic., Mikulka F; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 76001 Zlin, Czech Republic.; Centre of Polymer Systems, Tomas Bata University in Zlin, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic., Melánová K; Joint Laboratory of Solid State Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentska 84, 53210 Pardubice, Czech Republic., Knotek P; Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 53210 Pardubice, Czech Republic., Humeník M; Lehrstuhl Biomaterialien, Universitat Bayreuth, Prof.-Rudiger-Bormann Strasse 1, 95447 Bayreuth, Germany., Minařík A; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 76001 Zlin, Czech Republic.; Centre of Polymer Systems, Tomas Bata University in Zlin, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic., Mráček A; Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 76001 Zlin, Czech Republic.; Centre of Polymer Systems, Tomas Bata University in Zlin, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic.
Jazyk:	angličtina
Zdroj:	Biomacromolecules [Biomacromolecules] 2023 Jul 10; Vol. 24 (7), pp. 3016-3031. Date of Electronic Publication: 2023 May 30.
DOI:	10.1021/acs.biomac.3c00081
Abstrakt:	Layered nanoparticles with surface charge are explored as rheological modifiers for extrudable materials, utilizing their ability to induce electrostatic repulsion and create a house-of-cards structure. These nanoparticles provide mechanical support to the polymer matrix, resulting in increased viscosity and storage modulus. Moreover, their advantageous aspect ratio allows for shear-induced orientation and decreased viscosity during flow. In this work, we present a synthesis and liquid-based exfoliation procedure of phenylphosphonate-phosphate particles with enhanced ability to be intercalated by hydrophilic polymers. These layered nanoparticles are then tested as rheological modifiers of sodium alginate. The effective rheological modification is proved as the viscosity increases from 10 1 up to 10 3 Pa·s in steady state. Also, shear-thinning behavior is observed. The resulting nanocomposite hydrogels show potential as an extrudable bioink for 3D printing in tissue engineering and other biomedical applications, with good shape fidelity, nontoxicity, and satisfactory cell viability confirmed through encapsulation and printing of mouse fibroblasts.
Databáze:	MEDLINE
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