Humoral profiling of pediatric patients with cancer reveals robust immunity following anti-SARS-CoV-2 vaccination superior to natural infection.

Autor: Martin SD; Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA., Nziza N; Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard, Boston, Massachusetts, USA., Miozzo P; Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA., Bartsch Y; Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard, Boston, Massachusetts, USA., Farkas EJ; Department of Pediatrics, Pulmonary Division, Massachusetts General Hospital, Boston, Massachusetts, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA., Kane AS; Department of Pediatrics, Pulmonary Division, Massachusetts General Hospital, Boston, Massachusetts, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA., Boal LH; Department of Pediatrics, Hematology/Oncology Division, Massachusetts General Hospital, Boston, Massachusetts, USA., Friedmann A; Department of Pediatrics, Hematology/Oncology Division, Massachusetts General Hospital, Boston, Massachusetts, USA., Alter G; Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard, Boston, Massachusetts, USA.; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Yonker LM; Department of Pediatrics, Pulmonary Division, Massachusetts General Hospital, Boston, Massachusetts, USA.; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2023 Aug; Vol. 70 (8), pp. e30473. Date of Electronic Publication: 2023 May 30.
DOI: 10.1002/pbc.30473
Abstrakt: Background: Pediatric patients with cancer infected with COVID-19 may be at higher risk of severe disease and may be unable to mount an adequate response to the virus due to compromised immunity secondary to their cancer therapy.
Procedure: This study presents immunologic analyses of 20 pediatric patients with cancer, on active chemotherapy or having previously received chemotherapy, and measures their immunoglobulin titers and activation of cellular immunity response to acute SARS-CoV-2 infection and COVID-19 vaccination compared with healthy pediatric controls.
Results: Forty-three patients were enrolled, of which 10 were actively receiving chemotherapy, 10 had previously received chemotherapy, and 23 were healthy controls. Pediatric patients with cancer had similar immunoglobulin titers, antibody binding capacity, and effector function assay activity after vaccination against COVID-19 compared with healthy controls, though more variability in response was noted in the cohort actively receiving chemotherapy. Compared with acute infection, vaccination against COVID-19 produced superior immunoglobulin responses, particularly IgA1, IgG1, and IgG3, and elicited superior binding capacity and effector function in children with cancer and healthy controls.
Conclusions: Pediatric patients receiving chemotherapy and those who had previously received chemotherapy had adequate immune activation after both vaccination and acute infection compared to healthy pediatric controls, although there was a demonstrated variability in response for the patients on active chemotherapy. Vaccination against COVID-19 produced superior immune responses compared to acute SARS-CoV-2 infection in pediatric patients with cancer and healthy children, underscoring the importance of vaccination even in previously infected individuals.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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