Tumor-Induced Osteomalacia- Like Syndrome with Rickets and Infantile Hepatic Hemangioendothelioma.

Autor: Biswal B; Department of Pediatrics, IMS & SUM Hospital, Bhubaneswar, 751003, Odisha, India., Aradhana A; Department of Pediatrics, IMS & SUM Hospital, Bhubaneswar, 751003, Odisha, India., Mohanty MD; Department of Pediatrics, IMS & SUM Hospital, Bhubaneswar, 751003, Odisha, India., Choudhury J; Department of Pediatrics, IMS & SUM Hospital, Bhubaneswar, 751003, Odisha, India., Behera BK; Department of Pediatrics, IMS & SUM Hospital, Bhubaneswar, 751003, Odisha, India., Beura S; Department of Pediatrics, IMS & SUM Hospital, Bhubaneswar, 751003, Odisha, India. beurasubhasree@gmail.com.
Jazyk: angličtina
Zdroj: Indian journal of pediatrics [Indian J Pediatr] 2024 Aug; Vol. 91 (8), pp. 842-844. Date of Electronic Publication: 2023 May 30.
DOI: 10.1007/s12098-023-04612-x
Abstrakt: Tumor-induced osteomalacia (TIO), a rare paraneoplastic syndrome is seen in association with the overproduction of fibroblast growth factor-23 (FGF-23) by certain mesenchymal tumors in adults. In children, these phosphaturic mesenchymal tumors produce features of rickets similar to TIO. This condition is characterized by elevated blood levels of FGF-23, low phosphate, low or normal active vitamin D, and high alkaline phosphatase. Though the removal of the tumor is curative; in cases where surgical resection is not possible, medical treatment is successful with phosphate and active vitamin D in the improvement of symptoms. The case of a child with features of rickets is presented here to illustrate the importance of identifying this rare condition and instituting appropriate intervention.
(© 2023. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.)
Databáze: MEDLINE
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