Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine.

Autor: Garofalo S; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy. stefano.garofalo@uniroma1.it., Cocozza G; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.; IRCCS Neuromed, Pozzilli, Italy., Mormino A; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy., Bernardini G; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Russo E; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Ielpo D; Department of Psychology and Centre for Research in Neurobiology D. Bovet, Sapienza University of Rome, Rome, Italy., Andolina D; Department of Psychology and Centre for Research in Neurobiology D. Bovet, Sapienza University of Rome, Rome, Italy., Ventura R; Department of Psychology and Centre for Research in Neurobiology D. Bovet, Sapienza University of Rome, Rome, Italy., Martinello K; IRCCS Neuromed, Pozzilli, Italy., Renzi M; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy., Fucile S; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.; IRCCS Neuromed, Pozzilli, Italy., Laffranchi M; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Mortari EP; B Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Carsetti R; B Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Sciumè G; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Sozzani S; IRCCS Neuromed, Pozzilli, Italy.; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Santoni A; IRCCS Neuromed, Pozzilli, Italy.; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Tremblay ME; Centre de Recherche CHU de Quebec-Université Laval, Quebec City, QC, Canada., Ransohoff RM; Third Rock Ventures, Boston, MA, USA., Limatola C; IRCCS Neuromed, Pozzilli, Italy. cristina.limatola@uniroma1.it.; Department of Physiology and Pharmacology, Sapienza University, Laboratory affiliated to Istituto Pasteur, Rome, Italy. cristina.limatola@uniroma1.it.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 May 29; Vol. 14 (1), pp. 3103. Date of Electronic Publication: 2023 May 29.
DOI: 10.1038/s41467-023-38899-3
Abstrakt: The mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells (ILC) 1 in the meningeal dura layer of adult mice. We describe that ILC1/NK cell-derived interferon-γ and acetylcholine can contribute to the modulation of brain homeostatic functions, shaping synaptic neuronal transmission and neurotransmitter levels with effects on mice behavior. In detail, the interferon-γ plays a role in the formation of non-spatial memory, tuning the frequency of GABAergic neurotransmission on cortical pyramidal neurons, while the acetylcholine is a mediator involved in the modulation of brain circuitries that regulate anxiety-like behavior. These findings disclose mechanisms of immune-to-brain communication that modulate brain functions under physiological conditions.
(© 2023. The Author(s).)
Databáze: MEDLINE
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