Longitudinal changes in gray matter correspond to changes in cognition across the lifespan: implications for theories of cognition.

Autor: Smith ET; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA. Electronic address: Evan.Smith1@utdallas.edu., Hennessee JP; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA., Wig GS; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Frank S; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA., Gonzalez H; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA., Bacci J; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA., Chan M; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA., Carreno CA; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA., Kennedy KM; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA., Rodrigue KM; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA., Hertzog C; School of Psychology, Georgia Institute of Technology, Atlanta, GA, USA., Park DC; School of Behavioral and Brain Sciences, Department of Psychology, Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2023 Sep; Vol. 129, pp. 1-14. Date of Electronic Publication: 2023 May 04.
DOI: 10.1016/j.neurobiolaging.2023.04.014
Abstrakt: The present study examines the association between gray matter volume and cognition. Studies that have examined this issue have focused primarily on older adults, whereas the present study examines the issue across the entire adult lifespan. A total of 463 adults, ages 20-88 at first assessment, were followed longitudinally across three assessments over 8-10years. Significant individual differences in a general cognition measure comprised of measures of speed of processing, working memory, and episodic memory were observed, as well as in measures of cortical and subcortical gray matter. Parallel process latent growth curve modeling showed a reliable relationship between decreases in cortical matter and cognitive decline across the entire adult lifespan, which persisted after controlling for age effects. Implications of these findings in relation to progression toward dementia, risk assessment, cognitive intervention, and environmental factors are discussed, as well as implications for theories of cognitive aging.
Competing Interests: Disclosure statement The authors have no actual or potential conflicts of interest.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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