Identification of Phytochemicals and Assessment of Hypoglycemic and Haematological Potentials of Terminalia catappa Linn leaf Extract in Alloxan-induced Diabetic Wistar Rats.
| Autor: | Ben EE; Department of Physiology, University of Uyo, Akwa Ibom State, Nigeria., Beshel JA; Department of Physiology, University of Calabar, Cross River State, Nigeria., Owu DU; Department of Physiology, University of Calabar, Cross River State, Nigeria., Palacios J; Laboratorio de Bioquímica Aplicada, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, 1110939, Chile., Nwokocha M; Department of Pathology, Faculty of Medical Sciences, University of the West Indies, Mona Campus, Kingston, Jamaica., Bórquez J; Laboratorio de Productos Naturales, Departamento de Química, Facultad Ciencias Básicas, Universidad de Antofagasta, Casilla 170, Antofagasta, Chile., Simirgiotis MJ; Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Casilla 567, Valdivia, 5090000, Chile., Nwokocha CR; Department of Basic Medical Sciences, Faculty of Medical Sciences, University of the West Indies, Mona Campus, Kingston, Jamaica. |
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| Jazyk: | angličtina |
| Zdroj: | Cardiovascular & hematological agents in medicinal chemistry [Cardiovasc Hematol Agents Med Chem] 2024; Vol. 22 (2), pp. 139-150. |
| DOI: | 10.2174/1871525721666230526152917 |
| Abstrakt: | Introduction: Hypoglycemia and anemia are associated with diabetes mellitus. Medicinal plants and orthodox drugs have been used for the management of this disease. This study aimed to validate the ethnomedical claims of Terminalia catappa Linn. leaf extract in reducing hyperglycemia and hematological potentials in alloxan-induced diabetic rats and to identify likely antidiabetic compounds. Materials and Methods: Ultra-high-performance liquid chromatography was used to identify the various phytochemical constituents. Male Wistar rats were randomly divided into five groups containing 6 rats per group. Group 1 (control) received 0.2 ml/kg of distilled water, group 2 received 130 mg/kg of T. catappa aqueous extract, groups 3-5 were diabetic and received 0.2 ml/g distilled water, 130 mg/kg T. catappa extract and 0.75 IU/kg insulin respectively for 14 days. Hematological parameters were measured and an oral glucose tolerance test was carried out using 2 g/kg body weight glucose. A histological analysis of the pancreas was done. Results: Twenty-five compounds identified as flavonoids, phenolic acids, tannins, and triterpenoids were detected. The blood glucose levels were significantly (p <0.05) elevated in DM groups but were significantly (p <0.05) reduced following Terminalia catappa leaves extract to DM groups. There was s significant (p <0.05) increase in insulin levels improved hematological parameters (RBC, WBC, and platelets), and increased islet population. Conclusion: These results suggest that T. catappa extract has hypoglycemic, insulinogenic, and hematopoietic potentials in diabetic condition and offer protection to the pancreas which could be attributed to the phytochemical constituents thereby justifying its use in traditional therapy. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Databáze: | MEDLINE |
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