Apelin and Visfatin Expression in Placental Tissue in Women With Preeclampsia and Overweight/Obesity.

Autor:	Braga APDSX; Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil., Silva DM; Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil., de Farias Lelis D; Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil., Farias RE; Department of Pathology, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil., Paraíso AF; Departament of Nursing, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil., Santos SHS; Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil., Martins AMEBL; Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil.; Department of Odontology, Montes Claros State University (Unimontes), Montes Claros, Brazil., Andrade JMO; Graduate Program in Health Sciences, State University of Montes Claros (Unimontes), Montes Claros, Brazil.; Department of Pathophysiology, State University of Montes Claros (Unimontes), Montes Claros, Brazil.
Jazyk:	angličtina
Zdroj:	Biological research for nursing [Biol Res Nurs] 2023 Oct; Vol. 25 (4), pp. 647-657. Date of Electronic Publication: 2023 May 28.
DOI:	10.1177/10998004231178835
Abstrakt:	Background: Preeclampsia (PE) is a multifunctional and multisystem disorder. Several factors favor the development of PE, including obesity. Cytokines are also expressed in the placenta, predisposing to local alterations that favor the development of distinct pathological processes, including PE. This study aimed to evaluate the apelin and visfatin mRNA expression in the placental tissue of women with preeclampsia and overweight/obesity and correlates with maternal and fetal variables. Methods: A cross-sectional analytical study was performed with 60 pregnant women and their newborns. Clinical, anthropometric, and laboratory variables were collected. Placental tissue samples were obtained, and the apelin and visfatin mRNA expression levels were assessed by qRT-PCR. Results: The main findings evidenced lower levels of apelin expression in overweight/obese women, accompanied by a negative correlation with BMI and pre-pregnancy weight; a higher expression of apelin was also observed in women with late PE and no personal history of PE. For visfatin levels, higher expression levels were observed in women with late PE and term delivery. Furthermore, a positive correlation was observed between visfatin levels and fetal anthropometric parameters, such as weight, length, and head circumference. Conclusion: Apelin levels were less expressed in overweight/obese women. Apelin and visfatin levels were correlated/associated with maternal-fetal variables.
Databáze:	MEDLINE
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