The effect of P53 expression and smoking/alcohol in P16(+) and P16(-) oropharyngeal carcinoma and risk classification: the Turkish Society of Radiation Oncology Head & Neck Study Group 01-002.

Autor: Ozkaya Akagunduz O; Department of Radiation Oncology, Ege University, Faculty of Medicine, Izmir, Turkey. Electronic address: ozakagunduz@gmail.com., Etit D; Department of Pathology, Istanbul Aydin University, Faculty of Medicine, Istanbul, Turkey., Yazici G; Department of Radiation Oncology, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Veral A; Department of Pathology, Ege University, Faculty of Medicine, Izmir, Turkey., Cetinayak O; Dokuzeylul University, Faculty of Medicine, Izmir, Turkey., Sarioglu S; Department of Pathology, Dokuzeylul University, Faculty of Medicine, Izmir, Turkey., Guler Tezel G; Department of Pathology, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Duru Birgi S; Department of Radiation Oncology, Ankara University, Faculty of Medicine, Ankara, Turkey., Yuksel S; Department of Pathology, Ankara University, Faculty of Medicine, Ankara, Turkey., Kara G; Department of Radiation Oncology, Ataturk Training and Research Hospital, Izmir, Turkey., Mustafayev TZ; Department of Radiation Oncology, Acibadem Maslak Hospital, Istanbul, Turkey., Tokat F; Department of Pathology, Acibadem MAA University, School of Medicine, Istanbul, Turkey., Ceylaner Bicakli B; Department of Radiation Oncology, Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey., Basak K; Department of Pathology, Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey., Esassolak M; Department of Radiation Oncology, Ege University, Faculty of Medicine, Izmir, Turkey., Akman F; Dokuzeylul University, Faculty of Medicine, Izmir, Turkey., Ozyar E; Department of Radiation Oncology, Acibadem MAA University, School of Medicine, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2023 Jul; Vol. 136 (1), pp. 80-90. Date of Electronic Publication: 2023 Apr 10.
DOI: 10.1016/j.oooo.2023.04.001
Abstrakt: Objective: The aim of this study is to categorize the risk groups of patients with oropharyngeal carcinoma (OPC) according to p16 and p53 status, smoking/alcohol consumption history, and other prognostic factors.
Study Design: The immunostaining of p16 and p53 of 290 patients was retrospectively evaluated. The history of smoking/alcohol consumption of each patient was noted. p16 and p53 staining patterns were reviewed. The results were compared with demographic findings and prognostic factors. Risk groups have been classified for the p16 status of patients.
Results: The median follow-up was 47 months (range 6-240). Five-year disease-free survival (DFS) rates for patients with p16 (+) and (-) were 76% and 36%, and overall survival rates were 83% vs 40%, respectively (HR = 0.34 [0.21-0.57], P < .0001), HR = 0.22 [0.12-0.40] P < .0001, respectively). p16(-), p53(+), heavy smoking/alcohol consumption, performance status; advanced T and N stages in patients with p16(-), and continuing smoking/alcohol consumption after treatment were found to be unfavorable risk factors. Five-year overall survival rates were 95%, 78%, and 36% for low, intermediate, and high-risk groups, respectively.
Conclusions: The results of our study have shown that p16 negativity in patients with oropharyngeal cancer was found to be an important prognostic factor, especially for those with lower p53 expression and not smoking/consuming alcohol.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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