Trait- and state-like co-activation pattern dynamics in current and remitted major depressive disorder.

Autor: Liu C; Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; China National Clinical Research Center for Mental Disorders (Xiangya), Changsha, Hunan, PR China., Belleau EL; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA; Harvard Medical School, Boston, MA, USA., Dong D; Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; China National Clinical Research Center for Mental Disorders (Xiangya), Changsha, Hunan, PR China., Sun X; Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; China National Clinical Research Center for Mental Disorders (Xiangya), Changsha, Hunan, PR China., Xiong G; Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; China National Clinical Research Center for Mental Disorders (Xiangya), Changsha, Hunan, PR China., Pizzagalli DA; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA; Harvard Medical School, Boston, MA, USA., Auerbach RP; Department of Psychiatry, Columbia University, New York, NY, USA., Wang X; Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; China National Clinical Research Center for Mental Disorders (Xiangya), Changsha, Hunan, PR China. Electronic address: wangxiang0916@csu.edu.cn., Yao S; Medical Psychological Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; China National Clinical Research Center for Mental Disorders (Xiangya), Changsha, Hunan, PR China. Electronic address: shuqiaoyao@csu.edu.cn.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2023 Sep 15; Vol. 337, pp. 159-168. Date of Electronic Publication: 2023 May 26.
DOI: 10.1016/j.jad.2023.05.074
Abstrakt: Background: Distinguishing between trait- and state-like neural alternations in major depressive disorder (MDD) may advance our understanding of this recurring disorder. We aimed to investigate dynamic functional connectivity alternations in unmedicated individuals with current or past MDD using co-activation pattern analyses.
Methods: Resting-state functional magnetic resonance imaging data were acquired from individuals with first-episode current MDD (cMDD, n = 50), remitted MDD (rMDD, n = 44), and healthy controls (HCs, n = 64). Using a data-driven consensus clustering technique, four whole-brain states of spatial co-activation were identified and associated metrics (dominance, entries, transition frequency) were analyzed with respect to clinical characteristics.
Results: Relative to rMDD and HC, cMDD showed increased dominance and entries of state 1 (primarily involving default mode network (DMN)), and decreased dominance of state 4 (mostly involving frontal-parietal network (FPN)). Among cMDD, state 1 entries correlated positively with trait rumination. Conversely, relative to cMDD and HC, individuals with rMDD were characterized by increased state 4 entries. Relative to HC, both MDD groups showed increased state 4-to-1 (FPN to DMN) transition frequency but reduction in state 3 (spanning visual attention, somatosensory, limbic networks), with the former metric specifically related to trait rumination.
Limitations: Further confirmation with longitudinal studies are required.
Conclusions: Regardless of symptoms, MDD was characterized by increased FPN-to-DMN transitions and reduced dominance of a hybrid network. State-related effect emerged in regions critically implicated in repetitive introspection and cognitive control. Asymptomatic individuals with past MDD were uniquely linked to increased FPN entries. Our findings identify trait-like brain network dynamics that might increase vulnerability to future MDD.
Competing Interests: Declaration of competing interest Over the past 3 years, Dr. Pizzagalli has received consulting fees from Albright Stonebridge Group, Boehringer Ingelheim, Compass Pathways, Concert Pharmaceuticals, Engrail Therapeutics, Neumora Therapeutics (former BlackThorn Therapeutics), Neurocrine Biosciences, Neuroscience Software, Otsuka Pharmaceuticals, Sunovion Pharmaceuticals, and Takeda Pharmaceuticals; honoraria from the Psychonomic Society and American Psychological Association (for editorial work) and Alkermes, and research funding from Bird Foundation, Brain and Behavior Research Foundation, Dana Foundation, Millennium Pharmaceuticals, NIMH, and Wellcome Leap. In addition, he has received stock options from Compass Pathways, Engrail Therapeutics, Neumora Therapeutics (former BlackThorn Therapeutics), and Neuroscience Software. In the past 3 years, Dr. Auerbach has been an unpaid consultant for Ksana Health, and he serves on the Research Grants Committee for the American Foundation for Suicide Prevention. Dr. Auerbach's research is funded through NIMH, Morgan Stanley Foundation, and the Tommy Fuss Fund. Dr. Belleau's research is funded by NIMH K23MH122668 and the Klingenstein Third Generation Foundation. All other authors confirm they have no disclosures to make in association with the work presented in this manuscript.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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