Neuroinflammation and hypersensitivity evidenced by the acute and 28-day repeated dose toxicity tests of ostrich oil in mice.

Autor: Santin JR; Postgraduate Programme in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., Kopp MAT; Biomedicine Course, School of Health Sciences, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., Correa TP; Postgraduate Programme in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., Melato J; Postgraduate Programme in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., Benvenutti L; Postgraduate Programme in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., Nunes R; Postgraduate Programme in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., Goldoni FC; Postgraduate Programme in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., Patel YBK; Biomedicine Course, School of Health Sciences, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., de Souza JA; Biomedicine Course, School of Health Sciences, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., Soczek SHDS; Programa de Pós-graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba, PR, Brazil; Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, PR, Brazil., Fernandes ES; Programa de Pós-graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba, PR, Brazil; Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, PR, Brazil., Pastor MVD; Postgraduate Programme in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., Klein Junior LC; Postgraduate Programme in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil., Apel MA; School of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Henriques AT; School of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Quintão NLM; Postgraduate Programme in Pharmaceutical Science, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil. Electronic address: nara.quintao@univali.br.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2023 Jul; Vol. 177, pp. 113852. Date of Electronic Publication: 2023 May 25.
DOI: 10.1016/j.fct.2023.113852
Abstrakt: The ostrich oil (OO) has been topically used for decades to treat skin diseases. Its oral use has been encouraged through e-commerce advertising several health benefits to OO without scientific evidence on its safety or effectiveness. This study presents the chromatographic profile of a commercially available OO and its acute and 28-day repeated dose in vivo toxicological profiles. OO anti-inflammatory and antinociceptive effects were also investigated. Omega-9 (ω-9; oleic acid; 34.6%) and -6 (linoleic acid; 14.9%) were detected as OO main constituents. A high single dose of the OO (2 g/kg of ω-9) demonstrated no or low acute toxicity. However, when orally treated with OO (30-300 mg/kg of ω-9) for 28 consecutive days, mice exhibited altered locomotor and exploratory activities, hepatic damage, and increased hindpaw sensitivity accompanied by increased levels of cytokine and brain-derived neurotrophic factor in their spinal cords and brains. Lack of anti-inflammatory or antinociceptive activities was also evidenced in 15-day-OO treated mice. These results indicate that chronic consumption of OO induces hepatic injury, in addition to neuroinflammation and subsequent hypersensitivity and behavioural changes. Thus, there is no evidence to support OO use to treating illness in humans.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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