Three-Dimensional Echocardiography and Global Longitudinal Strain in Follow-Up After Multisystem Inflammatory Syndrome in Children: Six-Month, Single-Center, Prospective Study.

Autor: Kamińska H; Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Warsaw, Poland., Rożnowska-Wójtowicz A; Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Warsaw, Poland., Cacko A; Department of Medical Informatics and Telemedicine, Medical University of Warsaw, Warsaw, Poland., Okarska-Napierała M; Department of Pediatrics with Clinical Decisions Unit, Medical University of Warsaw, Warsaw, Poland., Kuchar E; Department of Pediatrics with Clinical Decisions Unit, Medical University of Warsaw, Warsaw, Poland., Werner B; Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Warsaw, Poland. Electronic address: bozena.werner@wum.edu.pl.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2023 Sep; Vol. 260, pp. 113516. Date of Electronic Publication: 2023 May 26.
DOI: 10.1016/j.jpeds.2023.113516
Abstrakt: Objective: To assess the potential long-term cardiac effects after multisystem inflammatory syndrome in children (MIS-C) with cardiovascular involvement in the acute phase.
Study Design: Our prospective study involved children consecutively diagnosed with MIS-C between October 2020 and February 2022 and followed 6 weeks and 6 months after the disease. In patients with severe cardiac involvement during the acute phase, an additional check-up after 3 months was scheduled. In all patients at all check-ups, 3-dimensional echocardiography and global longitudinal strain (GLS) were used to assess ventricular function.
Results: The study enrolled 172 children aged 1-17 years (median, 8 years). The means of ejection fraction (EF) and GLS for both ventricles were within normal limits after 6 weeks with no relationship with initial severity: left ventricular EF (LVEF) 60% (59%-63%), LV GLS -21.08% (-18.63% to -23.2%), right ventricular (RV) EF 64% (62%-67%), and RV GLS -22.8% (-20.5% to -24.5%). Further, statistically significant improvement of LV function was observed after 6 months-LVEF 63% (62%-65%) and LV GLS -22.55% (-21.05% to -24.25%; P < .05); however, RV function remained unchanged. The group with severe cardiac involvement showed LV function recovery pattern with no significant improvement between 6 weeks and 3 months after MIS-C, while still improving between 3 and 6 months after discharge.
Conclusions: LV and RV function is within normal limits 6 weeks after MIS-C regardless of severity of cardiovascular involvement; LV function improves further between 6 weeks and 6 months after the disease. The long-term prognosis is optimistic with full recovery of cardiac function.
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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