The role of cerebellum in timing processing: A contingent negative variation study.

Autor: Mannarelli D; Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, Italy. Electronic address: daniela.mannarelli@uniroma1.it., Pauletti C; Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, Italy. Electronic address: caterina.pauletti@uniroma1.it., Petritis A; Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, Italy. Electronic address: alessia.petritis@uniroma1.it., Maffucci A; Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, Italy. Electronic address: andrea.maffucci@uniroma1.it., Currà A; Department of Medical-Surgical Sciences and Biotechnologies, A. Fiorini Hospital, Terracina, LT, Sapienza University of Rome, Polo Pontino, Latina, Italy. Electronic address: antonio.curra@uniroma1.it., Trompetto C; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy; Department of Neurosciences, IRCCS Ospedale Policlinico San Martino, Genova, Italy. Electronic address: ctrompetto@neurologia.unige.it., Marinelli L; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy; Department of Neurosciences, IRCCS Ospedale Policlinico San Martino, Genova, Italy. Electronic address: lucio.marinelli@unige.it., Fattapposta F; Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, Italy. Electronic address: francesco.fattapposta@uniroma1.it.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2023 Jun 21; Vol. 808, pp. 137301. Date of Electronic Publication: 2023 May 25.
DOI: 10.1016/j.neulet.2023.137301
Abstrakt: Time management is an important aspect of human behaviour and cognition. Several brain regions are thought to be involved in motor timing and time estimation tasks. However, subcortical regions such as the basal nuclei and cerebellum seem to play a role in timing control. The aim of this study was to investigate the role of the cerebellum in temporal processing. For this purpose, we transitorily inhibited cerebellar activity by means of cathodal transcranial direct current stimulation (tDCS) and studied the effects of this inhibition on contingent negative variation (CNV) parameters elicited during a S1-S2 motor task in healthy subjects. Sixteen healthy subjects underwent a S1-S2 motor task prior to and after cathodal and sham cerebellar tDCS in separate sessions. The CNV task consisted of a duration discrimination task in which subjects had to determine whether the duration of a probe interval trial was shorter (800 ms), longer (1600 ms), or equal to the target interval of 1200 ms. A reduction in total CNV amplitude emerged only after cathodal tDCS for short and target interval trials, while no differences were detected for the long interval trial. Errors were significantly higher after cathodal tDCS than at baseline evaluation of short and target intervals. No reaction time differences were found for any time interval after the cathodal and sham sessions. These results point to a role of the cerebellum in time perception. In particular, the cerebellum seems to regulate temporal interval discrimination for second and sub-second ranges.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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