A clinical overview of paediatric sarcoidosis: Multicentre experience from Turkey.

Autor:	Guliyeva V; Department of Pediatric Rheumatology, Istanbul School of Medicine, Istanbul University, Istanbul, Türkiye., Demirkan FG; Department of Pediatric Rheumatology, Istanbul School of Medicine, Istanbul University, Istanbul, Türkiye., Yiğit RE; Department of Pediatric Rheumatology, Ümraniye Research and Training Hospital, University of Health Science, Istanbul, Türkiye., Esen E; Department of Pediatric Rheumatology, Erciyes School of Medicine, Erciyes University, Kayseri, Türkiye., Bayındır Y; Division of Pediatric Rheumatology, Hacettepe School of Medicine, Hacettepe University, Ankara, Türkiye., Torun R; Division of Pediatric Rheumatology, Dokuz Eylül Faculty of Medicine, Dokuz Eylül University, İzmir, Türkiye., Kılbas G; Department of Pediatric Rheumatology, Pamukkale Faculty of Medicine, Pamukkale University, Denizli, Türkiye., Gezgin Yıldırım D; Department of Pediatric Rheumatology, Gazi Faculty of Medicine, Gazi University, Ankara, Türkiye., Otar Yener G; Department of Pediatric Rheumatology, Sanliurfa Training and Research Hospital, Sanliurfa, Türkiye., Cakan M; Department of Pediatric Rheumatology, Ümraniye Research and Training Hospital, University of Health Science, Istanbul, Türkiye., Demir F; Department of Pediatric Rheumatology, Acibadem Hospital, Istanbul,Türkiye., Özturk K; Department of Pediatric Rheumatology, Istanbul Medeniyet University, Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Istanbul, Türkiye., Baglan E; Department of Pediatric Rheumatology, University of Health Sciences, Dr. Sami Ulus Maternity and Child Health and Diseases Research and Training Hospital, Ankara, Türkiye., Yuksel S; Department of Pediatric Rheumatology, Pamukkale Faculty of Medicine, Pamukkale University, Denizli, Türkiye., Bakkaloglu SA; Department of Pediatric Rheumatology, Gazi Faculty of Medicine, Gazi University, Ankara, Türkiye., Bora Makay B; Division of Pediatric Rheumatology, Dokuz Eylül Faculty of Medicine, Dokuz Eylül University, İzmir, Türkiye., Paç Kısaarslan A; Department of Pediatric Rheumatology, Erciyes School of Medicine, Erciyes University, Kayseri, Türkiye., Oray M; Department of Ophthalmology, Istanbul School of Medicine, Istanbul University, Istanbul, Türkiye., Bilginer Y; Division of Pediatric Rheumatology, Hacettepe School of Medicine, Hacettepe University, Ankara, Türkiye., Eker Ömeroğlu R; Department of Pediatric Rheumatology, Istanbul School of Medicine, Istanbul University, Istanbul, Türkiye., Ozen S; Division of Pediatric Rheumatology, Hacettepe School of Medicine, Hacettepe University, Ankara, Türkiye., Sozeri B; Department of Pediatric Rheumatology, Ümraniye Research and Training Hospital, University of Health Science, Istanbul, Türkiye., Aktay Ayaz N; Department of Pediatric Rheumatology, Istanbul School of Medicine, Istanbul University, Istanbul, Türkiye.
Jazyk:	angličtina
Zdroj:	Modern rheumatology [Mod Rheumatol] 2024 Mar 28; Vol. 34 (3), pp. 639-645.
DOI:	10.1093/mr/road050
Abstrakt:	Objectives: We aimed to outline the demographic data, clinical spectrum, and treatment approach of sarcoidosis in a large group of patients and sought to figure out the variations of early-onset (EOS) and late-onset paediatric sarcoidosis (LOS). Methods: The study followed a retrospective-descriptive design, with the analysis of medical records of cases diagnosed as paediatric sarcoidosis. Results: Fifty-two patients were included in the study. The median age at disease onset and follow-up duration were 83 (28.2-119) and 24 (6-48) months, respectively. Ten (19.2%) cases had EOS (before 5th birthday) and 42 (80.7%) cases had LOS. The most common clinical findings at the time of the disease onset were ocular symptoms (40.4%) followed by joint manifestation (25%), dermatological symptoms (13.5%), and features related to multi-organ involvement (11.5%). Anterior uveitis was the most common (55%) one among ocular manifestations. Patients with EOS displayed joint, eye, and dermatological findings more commonly than patients with LOS. The recurrence rate of disease in patients with EOS (5.7%) and LOS (21.1%) were not statistically different (P = .7). Conclusions: Patients with EOS and LOS may present with variable clinical features and studies addressing paediatric sarcoidosis cases in collaboration between disciplines will enhance the awareness of this rare disease among physicians and assist early diagnosis with lesser complications. (© Japan College of Rheumatology 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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