Mechanistic Computational Modeling of Implantable, Bioresorbable Drug Release Systems.

Autor: Giolando PA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.; School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Hopkins K; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Davis BF; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Vike N; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Ahmadzadegan A; School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Ardekani AM; School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Vlachos PP; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.; School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Rispoli JV; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Solorio L; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Kinzer-Ursem TL; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2023 Dec; Vol. 35 (51), pp. e2301698. Date of Electronic Publication: 2023 Sep 08.
DOI: 10.1002/adma.202301698
Abstrakt: Implantable, bioresorbable drug delivery systems offer an alternative to current drug administration techniques; allowing for patient-tailored drug dosage, while also increasing patient compliance. Mechanistic mathematical modeling allows for the acceleration of the design of the release systems, and for prediction of physical anomalies that are not intuitive and may otherwise elude discovery. This study investigates short-term drug release as a function of water-mediated polymer phase inversion into a solid depot within hours to days, as well as long-term hydrolysis-mediated degradation and erosion of the implant over the next few weeks. Finite difference methods are used to model spatial and temporal changes in polymer phase inversion, solidification, and hydrolysis. Modeling reveals the impact of non-uniform drug distribution, production and transport of H + ions, and localized polymer degradation on the diffusion of water, drug, and hydrolyzed polymer byproducts. Compared to experimental data, the computational model accurately predicts the drug release during the solidification of implants over days and drug release profiles over weeks from microspheres and implants. This work offers new insight into the impact of various parameters on drug release profiles, and is a new tool to accelerate the design process for release systems to meet a patient specific clinical need.
(© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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