The role of microbiota and its modulation in colonic diverticular disease.

Autor: Marasco G; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Science, University of Bologna, Bologna, Italy., Buttitta F; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Science, University of Bologna, Bologna, Italy., Cremon C; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Barbaro MR; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Stanghellini V; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Science, University of Bologna, Bologna, Italy., Barbara G; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Science, University of Bologna, Bologna, Italy.
Jazyk: angličtina
Zdroj: Neurogastroenterology and motility [Neurogastroenterol Motil] 2023 Dec; Vol. 35 (12), pp. e14615. Date of Electronic Publication: 2023 May 27.
DOI: 10.1111/nmo.14615
Abstrakt: Background: Diverticular disease (DD) is a common condition in Western countries. The role of microbiota in the pathogenesis of DD and its related symptoms has been frequently postulated since most complications of this disease are bacteria-driven and most therapies rely on microbiota modulation. Preliminary data showed fecal microbial imbalance in patients with DD, particularly when symptomatic, with an increase of pro-inflammatory and potentially pathogenetic bacteria. In addition, bacterial metabolic markers can mirror specific pathways of the disease and may be even used for monitoring treatment effects. All treatments currently suggested for DD can affect microbiota structure and metabolome compositions.
Purpose: Sparse evidence is available linking gut microbiota perturbations, diverticular disease pathophysiology, and symptom development. We aimed to summarize the available knowledge on gut microbiota evaluation in diverticular disease, with a focus on symptomatic uncomplicated DD, and the relative treatment strategies.
(© 2023 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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