| Autor: |
Hakim Khalili M; Surface Engineering and Precision Centre, School of Aerospace, Transport and Manufacturing, Cranfield University, Bedford MK43 0AL, UK., Zhang R; Sophion Bioscience A/S, Baltorpvej 154, 2750 Copenhagen, Denmark., Wilson S; Sophion Bioscience A/S, Baltorpvej 154, 2750 Copenhagen, Denmark., Goel S; School of Engineering, London South Bank University, 103 Borough Road, London SE1 0AA, UK.; Department of Mechanical Engineering, University of Petroleum and Energy Studies, Dehradun 248007, India., Impey SA; Surface Engineering and Precision Centre, School of Aerospace, Transport and Manufacturing, Cranfield University, Bedford MK43 0AL, UK., Aria AI; Surface Engineering and Precision Centre, School of Aerospace, Transport and Manufacturing, Cranfield University, Bedford MK43 0AL, UK. |
| Abstrakt: |
In this brief review, we discuss the recent advancements in using poly(ethylene glycol) diacrylate (PEGDA) hydrogels for tissue engineering applications. PEGDA hydrogels are highly attractive in biomedical and biotechnology fields due to their soft and hydrated properties that can replicate living tissues. These hydrogels can be manipulated using light, heat, and cross-linkers to achieve desirable functionalities. Unlike previous reviews that focused solely on material design and fabrication of bioactive hydrogels and their cell viability and interactions with the extracellular matrix (ECM), we compare the traditional bulk photo-crosslinking method with the latest three-dimensional (3D) printing of PEGDA hydrogels. We present detailed evidence combining the physical, chemical, bulk, and localized mechanical characteristics, including their composition, fabrication methods, experimental conditions, and reported mechanical properties of bulk and 3D printed PEGDA hydrogels. Furthermore, we highlight the current state of biomedical applications of 3D PEGDA hydrogels in tissue engineering and organ-on-chip devices over the last 20 years. Finally, we delve into the current obstacles and future possibilities in the field of engineering 3D layer-by-layer (LbL) PEGDA hydrogels for tissue engineering and organ-on-chip devices. |
