Pharmacological Functions, Synthesis, and Delivery Progress for Collagen as Biodrug and Biomaterial.

Autor: Zhou N; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Liu YD; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Zhang Y; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Gu TW; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Peng LH; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2023 May 09; Vol. 15 (5). Date of Electronic Publication: 2023 May 09.
DOI: 10.3390/pharmaceutics15051443
Abstrakt: Collagen has been widely applied as a functional biomaterial in regulating tissue regeneration and drug delivery by participating in cell proliferation, differentiation, migration, intercellular signal transmission, tissue formation, and blood coagulation. However, traditional extraction of collagen from animals potentially induces immunogenicity and requires complicated material treatment and purification steps. Although semi-synthesis strategies such as utilizing recombinant E. coli or yeast expression systems have been explored as alternative methods, the influence of unwanted by-products, foreign substances, and immature synthetic processes have limited its industrial production and clinical applications. Meanwhile, macromolecule collagen products encounter a bottleneck in delivery and absorption by conventional oral and injection vehicles, which promotes the studies of transdermal and topical delivery strategies and implant methods. This review illustrates the physiological and therapeutic effects, synthesis strategies, and delivery technologies of collagen to provide a reference and outlook for the research and development of collagen as a biodrug and biomaterial.
Databáze: MEDLINE
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