| Autor: |
Quiñones J; Posgrado en Nanotecnología, Departamento de Física, Universidad de Sonora, Unidad Regional Centro, Hermosillo 83000, Mexico., Miranda-Castro FC; Posgrado en Nanotecnología, Departamento de Física, Universidad de Sonora, Unidad Regional Centro, Hermosillo 83000, Mexico., Encinas-Basurto D; Departamento de Física, Matemáticas e Ingeniería, Universidad de Sonora, Campus Navojoa, Navojoa 85880, Mexico., Ibarra J; Departamento de Física, Matemáticas e Ingeniería, Universidad de Sonora, Campus Navojoa, Navojoa 85880, Mexico., Moran-Palacio EF; Departamento de Ciencias Químico-Biológicas y Agropecuarias, Universidad de Sonora, Lázaro Cárdenas 100, Colonia Francisco Villa, Navojoa 85880, Mexico., Zamora-Alvarez LA; Departamento de Ciencias Químico-Biológicas y Agropecuarias, Universidad de Sonora, Lázaro Cárdenas 100, Colonia Francisco Villa, Navojoa 85880, Mexico., Almada M; Departamento de Ciencias Químico-Biológicas y Agropecuarias, Universidad de Sonora, Lázaro Cárdenas 100, Colonia Francisco Villa, Navojoa 85880, Mexico. |
| Abstrakt: |
The versatile combination of metal nanoparticles with chemotherapy agents makes designing multifunctional drug delivery systems attractive. In this work, we reported cisplatin's encapsulation and release profile using a mesoporous silica-coated gold nanorods system. Gold nanorods were synthesized by an acidic seed-mediated method in the presence of cetyltrimethylammonium bromide surfactant, and the silica-coated state was obtained by modified Stöber method. The silica shell was modified first with 3-aminopropyltriethoxysilane and then with succinic anhydride to obtain carboxylates groups to improve cisplatin encapsulation. Gold nanorods with an aspect ratio of 3.2 and silica shell thickness of 14.74 nm were obtained, and infrared spectroscopy and ζ potential studies corroborated surface modification with carboxylates groups. On the other hand, cisplatin was encapsulated under optimal conditions with an efficiency of ~58%, and it was released in a controlled manner over 96 h. Furthermore, acidic pH promoted a faster release of 72% cisplatin encapsulated compared to 51% in neutral pH. |
