| Autor: |
Brănișteanu DE; Dermatology Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Railway Clinical Hospital, 700506 Iasi, Romania., Porumb-Andrese E; Dermatology Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Railway Clinical Hospital, 700506 Iasi, Romania., Stărică A; Dermatology Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Railway Clinical Hospital, 700506 Iasi, Romania., Munteanu AC; Dermatology Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Railway Clinical Hospital, 700506 Iasi, Romania., Toader MP; Railway Clinical Hospital, 700506 Iasi, Romania., Zemba M; Ophthalmology Department, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Porumb V; Department Surgery, 'Grigore T. Popa' University of Medicine and Pharmacy, 700111 Iasi, Romania., Cozmin M; Clinical Department, Apollonia University of Iasi, 700511 Iasi, Romania., Moraru AD; Ophthalmology Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Nicolescu AC; Roma Medical Center for Diagnosis and Treatment, 011773 Bucharest, Romania.; 'Agrippa Ionescu' Emergency Clinical Hospital, 011773 Bucharest, Romania., Brănișteanu DC; Railway Clinical Hospital, 700506 Iasi, Romania.; Ophthalmology Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania. |
| Abstrakt: |
Both cutaneous melanoma (CM) and uveal melanoma (UM) represent important causes of morbidity and mortality. In this review, we evaluate the available knowledge on the differences and similarities between cutaneous melanoma and uveal melanoma, focusing on the epidemiological aspects and risk factors. Uveal melanoma is a rare condition but is the most prevalent primary intra-ocular malignant tumor in adults. Cutaneous melanoma, on the other hand, is significantly more common. While the frequency of cutaneous melanoma has increased in the last decades worldwide, the incidence of uveal melanoma has remained stable. Although both tumors arise from melanocytes, they are very distinct entities biologically, with complex and varied etiologies. Both conditions are encountered more frequently by individuals with a fair phenotype. ultraviolet-radiation is an important, well-documented risk factor for the development of CM, but has shown not to be of specific risk in UM. Although cutaneous and ocular melanomas seem to be inherited independently, there are reported cases of concomitant primary tumors in the same patient. |
