Endotypes of Nasal Polyps in Children: A Multidisciplinary Approach.

Autor: Sitzia E; Department of Otorhinolaryngology, Children's Hospital 'Ospedale Pediatrico Bambino Gesù-IRCCS', 00165 Rome, Italy., Santarsiero S; Department of Otorhinolaryngology, Children's Hospital 'Ospedale Pediatrico Bambino Gesù-IRCCS', 00165 Rome, Italy., Marini G; Department of Otorhinolaryngology, Children's Hospital 'Ospedale Pediatrico Bambino Gesù-IRCCS', 00165 Rome, Italy., Majo F; Department of Cystic Fibrosis, Children's Hospital 'Ospedale Pediatrico Bambino Gesù-IRCCS', 00165 Rome, Italy., De Vincentiis M; Faculty of Medicine and Surgery, University 'Università Degli Studi Tor Vergata di Roma', 00133 Rome, Italy., Cristalli G; Department of Otorhinolaryngology, Children's Hospital 'Ospedale Pediatrico Bambino Gesù-IRCCS', 00165 Rome, Italy., Artesani MC; Department of Allergology, Children's Hospital 'Ospedale Pediatrico Bambino Gesù-IRCCS', 00165 Rome, Italy., Fiocchi AG; Department of Allergology, Children's Hospital 'Ospedale Pediatrico Bambino Gesù-IRCCS', 00165 Rome, Italy.
Jazyk: angličtina
Zdroj: Journal of personalized medicine [J Pers Med] 2023 Apr 23; Vol. 13 (5). Date of Electronic Publication: 2023 Apr 23.
DOI: 10.3390/jpm13050707
Abstrakt: Nasal polyps (NPs) are rarely reported in childhood and usually represent red flags for systemic diseases, such as cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and immunodeficiencies. The European Position Paper released in 2020 (EPOS 2020) provided a detailed classification and defined the correct diagnostic and therapeutic approaches. We report a one-year experience of a multidisciplinary team, made up of otorhinolaryngologists, allergists, pediatricians, pneumologists and geneticists, with the aim of ensuring a personalized diagnostic and therapeutic management of the pathology. In 16 months of activity, 53 patients were admitted (25 children with chronic rhinosinusitis with polyposis and 28 with antro-choanal polyp). All patients underwent phenotypic and endo-typic assessment, using proper classification tools for nasal pathology (both endoscopic and radiological), as well as adequate cytological definition. An immuno-allergic evaluation was carried out. Pneumologists evaluated any lower airway respiratory disease. Genetic investigations concluded the diagnostic investigation. Our experience enhanced the complexity of children's NPs. A multidisciplinary assessment is mandatory for a targeted diagnostic and therapeutic pathway.
Databáze: MEDLINE