Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs.

Autor: Kumari L; Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga 142001, Punjab, India., Choudhari Y; Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga 142001, Punjab, India., Patel P; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, GT Road, Moga 142001, Punjab, India., Gupta GD; Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga 142001, Punjab, India., Singh D; Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga 142001, Punjab, India., Rosenholm JM; Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland., Bansal KK; Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland., Kurmi BD; Department of Pharmaceutics, ISF College of Pharmacy, GT Road, Moga 142001, Punjab, India.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2023 Apr 27; Vol. 13 (5). Date of Electronic Publication: 2023 Apr 27.
DOI: 10.3390/life13051099
Abstrakt: A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products and 70-90% of drug candidates in the development stage are poorly soluble, which results in low bioavailability, diminished therapeutic effects, and dosage escalation. Because of this, solubility must be taken into consideration when developing and fabricating pharmaceutical products. To date, a number of approaches have been investigated to address the problem of poor solubility. This review article attempts to summarize several conventional methods utilized to increase the solubility of poorly soluble drugs. These methods include the principles of physical and chemical approaches such as particle size reduction, solid dispersion, supercritical fluid technology, cryogenic technology, inclusion complex formation techniques, and floating granules. It includes structural modification (i.e., prodrug, salt formation, co-crystallization, use of co-solvents, hydrotrophy, polymorphs, amorphous solid dispersions, and pH variation). Various nanotechnological approaches such as liposomes, nanoparticles, dendrimers, micelles, metal organic frameworks, nanogels, nanoemulsions, nanosuspension, carbon nanotubes, and so forth have also been widely investigated for solubility enhancement. All these approaches have brought forward the enhancement of the bioavailability of orally administered drugs by improving the solubility of poorly water-soluble drugs. However, the solubility issues have not been completely resolved, owing to several challenges associated with current approaches, such as reproducibility in large scale production. Considering that there is no universal approach for solving solubility issues, more research is needed to simplify the existing technologies, which could increase the number of commercially available products employing these techniques.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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