| Autor: |
Chumachenko PV; Petrovsky National Russian Research Center of Surgery, Lane Abrikosovsky, 2, 119991 Moscow, Russia.; National Medical Research Center of Cardiology, Academician Chazova St., 15a, 121552 Moscow, Russia., Ivanova AG; Petrovsky National Russian Research Center of Surgery, Lane Abrikosovsky, 2, 119991 Moscow, Russia., Bagheri Ekta M; Petrovsky National Russian Research Center of Surgery, Lane Abrikosovsky, 2, 119991 Moscow, Russia., Omelchenko AV; Institute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia., Sukhorukov VN; Petrovsky National Russian Research Center of Surgery, Lane Abrikosovsky, 2, 119991 Moscow, Russia., Markin AM; Petrovsky National Russian Research Center of Surgery, Lane Abrikosovsky, 2, 119991 Moscow, Russia.; Peoples' Friendship University of Russia Named after Patrice Lumumba (RUDN University), Miklukho-Maklaya St., 6, 117198 Moscow, Russia., Markina YV; Petrovsky National Russian Research Center of Surgery, Lane Abrikosovsky, 2, 119991 Moscow, Russia., Postnov AY; Petrovsky National Russian Research Center of Surgery, Lane Abrikosovsky, 2, 119991 Moscow, Russia.; National Medical Research Center of Cardiology, Academician Chazova St., 15a, 121552 Moscow, Russia. |
| Abstrakt: |
It is known that vasa vasorum contributes substantially to the blood supply and nutrition of one-third of the wall of the ascending thoracic aorta. Therefore, we focused on studying the relationship between inflammatory cells and vasa vasorum vessels in patients with aortic aneurysm. The material for the study was biopsies of thoracic aortic aneurysms taken from patients during an aneurysmectomy (34 men, 14 women, aged 33 to 79 years). The biopsies belonged to patients with non-hereditary thoracic aortic aneurysm. An immunohistochemical study was carried out using antibodies to antigens of T cells (CD3, CD4, CD8); macrophages (CD68); B cells (CD20); endothelium (CD31, CD34, von Willebrand factor (vWF)); and smooth muscle cells (alpha actin). Samples without inflammatory infiltrates contained less vasa vasorum in the tunica adventitia than samples with inflammatory infiltrates, and this difference was statistically significant p < 0.05. T cell infiltrates in the adventitia of aortic aneurysms were found in 28 of 48 patients. In the vessels of the vasa vasorum, surrounded by inflammatory infiltrates, T cells that adhered to the endothelium were found. The same cells were also localized in the subendothelial area. The number of adherent T cells in patients with inflammatory infiltrates in the aortic wall dominated the number of these cells in patients without inflammation of the aortic wall. This difference was statistically significant, p < 0.0006. Hypertrophy and sclerosis of the arteries of the vasa vasorum system, the narrowing of their lumen, and, as a result, impaired blood supply to the aortic wall, were found in 34 patients with hypertension. In 18 patients (both in patients with hypertension and in patients without hypertension), T cells that adhered to the vasa vasorum endothelium were found. In nine cases, massive infiltrates of T cells and macrophages were found, which surrounded and squeezed the vasa vasorum, preventing blood circulation. In six patients, parietal and obturating blood clots were found in the vasa vasorum vessels, which disrupted the normal blood supply to the aortic wall. We believe that this indicates the importance of the state of the vessels of the vasa vasorum in the development of an aortic aneurysm. In addition, pathological changes in these vessels may not always play a primary role, but always a very important role, in the pathogenesis of this disease. |
