| Autor: |
Trofin F; Microbiology Department, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Clinical Hospital of Infectious Diseases 'Sfânta Parascheva', 700116 Iasi, Romania., Nastase EV; Clinical Hospital of Infectious Diseases 'Sfânta Parascheva', 700116 Iasi, Romania.; Infectious Diseases Department, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania., Roșu MF; Clinical Hospital of Infectious Diseases 'Sfânta Parascheva', 700116 Iasi, Romania.; Department of Dento-Alveolar Surgery, Anesthesia, Sedation, and Medical-Surgical Emergencies, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania., Bădescu AC; Microbiology Department, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Clinical Hospital of Infectious Diseases 'Sfânta Parascheva', 700116 Iasi, Romania., Buzilă ER; Iasi Regional Center for Public Health, National Institute of Public Health, 700465 Iasi, Romania., Miftode EG; Clinical Hospital of Infectious Diseases 'Sfânta Parascheva', 700116 Iasi, Romania.; Infectious Diseases Department, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania., Manciuc DC; Clinical Hospital of Infectious Diseases 'Sfânta Parascheva', 700116 Iasi, Romania.; Infectious Diseases Department, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania., Dorneanu OS; Microbiology Department, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Clinical Hospital of Infectious Diseases 'Sfânta Parascheva', 700116 Iasi, Romania. |
| Abstrakt: |
The aim of this study was to analyze the serum concentration of interleukin-6 (IL-6), C-reactive protein (CRP), D-dimer, lactate dehydrogenase (LDH), ferritin, and procalcitonin in COVID-19 patients with different forms of the disease. We performed a prospective cohort study on 137 COVID-19 consecutive patients, divided into four groups according to the severity of the disease as follows: 30 patients in the mild form group, 49 in the moderate form group, 28 in the severe form group, and 30 in the critical form group. The tested parameters were correlated with COVID-19 severity. Significant differences were registered between the form of COVID-19 depending on the vaccination status, between LDH concentrations depending on the virus variant, and in IL-6, CRP, and ferritin concentrations and vaccination status depending on the gender. ROC analysis revealed that D-dimer best predicted COVID-19 severe forms and LDH predicted the virus variant. Our findings confirmed the interdependence relationships observed between inflammation markers in relation to the clinical severity of COVID-19, with all the tested biomarkers increasing in severe and critical COVID-19. IL-6, CRP, ferritin, LDH, and D-dimer were increased in all COVID-19 forms. These inflammatory markers were lower in Omicron-infected patients. The unvaccinated patients developed more severe forms compared to the vaccinated ones, and a higher proportion of them needed hospitalization. D-dimer could predict a severe form of COVID-19, while LDH could predict the virus variant. |
