Supplement Treatment with NAC and Omega-3 Polyunsaturated Fatty Acids during Pregnancy Partially Prevents Schizophrenia-Related Outcomes in the Poly I:C Rat Model.

Autor:	Edemann-Callesen H; Department of Psychiatry and Neuroscience, Campus Mitte, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany., Bernhardt N; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität, 01307 Dresden, Germany., Hlusicka EB; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität, 01307 Dresden, Germany., Hintz F; Department of Psychiatry and Neuroscience, Campus Mitte, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany., Habelt B; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität, 01307 Dresden, Germany.; Leibniz Institute of Polymer Research Dresden, 01069 Dresden, Germany., Winter R; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität, 01307 Dresden, Germany., Neubert I; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität, 01307 Dresden, Germany., Pelz M; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität, 01307 Dresden, Germany., Filla A; Department of Psychiatry and Psychotherapy, Medical Faculty Carl Gustav Carus, Technische Universität, 01307 Dresden, Germany., Soto-Montenegro ML; Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain.; CIBER de Salud Mental, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Grupo de Investigación de Alto Rendimiento en Fisiopatología y Farmacología del Sistema Digestivo (NeuGut-URJC), Universidad Rey Juan Carlos, 28922 Alcorcón, Spain., Winter C; Department of Psychiatry and Neuroscience, Campus Mitte, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany., Hadar R; Department of Psychiatry and Neuroscience, Campus Mitte, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Jazyk:	angličtina
Zdroj:	Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 May 09; Vol. 12 (5). Date of Electronic Publication: 2023 May 09.
DOI:	10.3390/antiox12051068
Abstrakt:	Background: Heightened levels of inflammation and oxidative stress are thought to be involved in the pathophysiology of schizophrenia. We aimed to assess whether intake of anti-inflammatory and anti-oxidant drugs during pregnancy prevents later schizophrenia-related outcomes in a neurodevelopmental rat model of this disorder. Methods: Pregnant Wistar rats were injected with polyriboinosinic-polyribocytidilic acid (Poly I:C) or saline and subsequently treated with either N-acetyl cysteine (NAC) or omega-3 polyunsaturated fatty acids (PUFAs) until delivery. Controls rats received no treatment. In the offspring, neuroinflammation and anti-oxidant enzyme activity were assessed on postnatal day (PND) 21, 33, 48, and 90. Behavioral testing was performed at PND 90, followed by post-mortem neurochemical assessment and ex vivo MRI. Results: The supplement treatment led to a quicker restoration of the wellbeing of dams. In the adolescent Poly I:C offspring, the supplement treatment prevented an increase in microglial activity and partially prevented a deregulation in the anti-oxidant defense system. In the adult Poly I:C offspring, supplement treatment partially prevented dopamine deficits, which was paralleled by some changes in behavior. Exposure to omega-3 PUFAs prevented the enlargement of lateral ventricles. Conclusion: Intake of over-the-counter supplements may assist in especially targeting the inflammatory response related to schizophrenia pathophysiology, aiding in diminishing later disease severity in the offspring.
Databáze:	MEDLINE
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