| Autor: |
Santos-Silva CAD; Institute for Maternal and Child Health-IRCCS Burlo Garofolo, 34137 Trieste, Italy., Ferreira-Neto JRC; Departamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Amador VC; Departamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Bezerra-Neto JP; Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife 50100-010, Brazil., Vilela LMB; Departamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Binneck E; Empresa Brasileira de Pesquisa Agropecuária, Embrapa Soja, Londrina 86085-981, Brazil., Rêgo MS; Departamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., da Silva MD; Departamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Mangueira de Melo ALT; Departamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., da Silva RH; Departamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil., Benko-Iseppon AM; Departamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil. |
| Abstrakt: |
Non-specific lipid transfer proteins (nsLTPs) stand out among plant-specific peptide superfamilies due to their multifaceted roles in plant molecular physiology and development, including their protective functions against pathogens. These antimicrobial agents have demonstrated remarkable efficacy against bacterial and fungal pathogens. The discovery of plant-originated, cysteine-rich antimicrobial peptides such as nsLTPs has paved the way for exploring the mentioned organisms as potential biofactories for synthesizing antimicrobial compounds. Recently, nsLTPs have been the focus of a plethora of research and reviews, providing a functional overview of their potential activity. The present work compiles relevant information on nsLTP omics and evolution, and it adds meta-analysis of nsLTPs, including: (1) genome-wide mining in 12 plant genomes not studied before; (2) latest common ancestor analysis (LCA) and expansion mechanisms; (3) structural proteomics, scrutinizing nsLTPs' three-dimensional structure/physicochemical characteristics in the context of nsLTP classification; and (4) broad nsLTP spatiotemporal transcriptional analysis using soybean as a study case. Combining a critical review with original results, we aim to integrate high-quality information in a single source to clarify unexplored aspects of this important gene/peptide family. |
