Male pattern hair loss: Can developmental origins explain the pattern?

Autor: Redmond LC; Department of Bioengineering, Imperial College London, London, UK., Limbu S; Department of Bioengineering, Imperial College London, London, UK., Farjo B; Farjo Hair Institute, Manchester, UK., Messenger AG; Department of Dermatology, University of Sheffield, Sheffield, UK., Higgins CA; Department of Bioengineering, Imperial College London, London, UK.
Jazyk: angličtina
Zdroj: Experimental dermatology [Exp Dermatol] 2023 Jul; Vol. 32 (7), pp. 1174-1181. Date of Electronic Publication: 2023 May 26.
DOI: 10.1111/exd.14839
Abstrakt: Male pattern hair loss (MPHL), also referred to as male androgenetic alopecia (AGA) is the most common type of non-scarring progressive hair loss, with 80% of men suffering from this condition in their lifetime. In MPHL, the hair line recedes to a specific part of the scalp which cannot be accurately predicted. Hair is lost from the front, vertex, and the crown, yet temporal and occipital follicles remain. The visual effect of hair loss is due to hair follicle miniaturisation, where terminal hair follicles become dimensionally smaller. Miniaturisation is also characterised by a shortening of the growth phase of the hair cycle (anagen), and a prolongation of the dormant phase (kenogen). Together, these changes result in the production of thinner and shorter hair fibres, referred to as miniaturised or vellus hairs. It remains unclear why miniaturisation occurs in this specific pattern, with frontal follicles being susceptible while occipital follicles remain in a terminal state. One main factor we believe to be at play, which will be discussed in this viewpoint, is the developmental origin of the skin and hair follicle dermis on different regions of the scalp.
(© 2023 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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