Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.

Autor: Shi J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. jianxin.shi@nih.gov., Shiraishi K; Division of Genome Biology, National Cancer Research Institute, Tokyo, Japan., Choi J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Matsuo K; Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan., Chen TY; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan., Dai J; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China., Hung RJ; Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada., Chen K; Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA., Kim YT; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Landi MT; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Lin D; Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA., Yin Z; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China., Zhou B; Department of Clinical Epidemiology and Center of Evidence Based Medicine, The First Hospital of China Medical University, Shenyang, China., Song B; Department of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China., Wang J; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China., Seow WJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Song L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Chang IS; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan., Hu W; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Chien LH; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan., Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA., Hong YC; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Kim HN; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea., Wu YL; Guangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China., Wong MP; Department of Pathology, Queen Mary Hospital, Hong Kong, Hong Kong., Richardson BD; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Funderburk KM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Li S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Department of Biostatistics, Bioinformatics & Biomathematics, Georgetown University Medical Center, Washington, DC, USA., Zhang T; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Breeze C; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Wang Z; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Blechter B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Bassig BA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Kim JH; Department of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Wong JYY; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Shin MH; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea., Chung LP; Department of Pathology, Queen Mary Hospital, Hong Kong, Hong Kong., Yang Y; Shanghai Pulmonary Hospital, Shanghai, China., An SJ; Guangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China., Zheng H; Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China., Yatabe Y; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan., Zhang XC; Guangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China., Kim YC; Lung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasuneup, Republic of Korea.; Department of Internal Medicine, Chonnam National Univerisity Medical School, Gwangju, Republic of Korea., Caporaso NE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Chang J; Department of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Ho JCM; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong., Kubo M; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Daigo Y; Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Medical Oncology and Cancer Center, and Center for Advanced Medicine against Cancer, Shiga University of Medical Science, Shiga, Japan., Song M; Department of Statistics & Research Institute of Natural Sciences, Sookmyung Women's University, Seoul, Republic of Korea., Momozawa Y; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kobayashi M; Department of Thoracic Surgery, Tokyo Medical and Dental University, Tokyo, Japan., Okubo K; Department of Thoracic Surgery, Tokyo Medical and Dental University, Tokyo, Japan., Honda T; Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan., Hosgood DH; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Kunitoh H; Department of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan., Patel H; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Watanabe SI; Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan., Miyagi Y; Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan., Nakayama H; Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan., Matsumoto S; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Horinouchi H; Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan., Tsuboi M; Department of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan., Hamamoto R; Division of Medical AI Research and Development, National Cancer Center Research Institute, Tokyo, Japan., Goto K; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Ohe Y; Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan., Takahashi A; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Goto A; Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita, Japan., Minamiya Y; Department of Thoracic Surgery, Graduate School of Medicine, Akita University, Akita, Japan., Hara M; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan., Nishida Y; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan., Takeuchi K; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan., Wakai K; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan., Matsuda K; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Murakami Y; Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Shimizu K; Department of Surgery, Division of General Thoracic Surgery, Shinshu University School of Medicine Asahi, Nagano, Japan., Suzuki H; Department of Chest Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan., Saito M; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan., Ohtaki Y; Department of Integrative center of General Surgery, Gunma University Hospital, Gunma, Japan., Tanaka K; Department of Integrative center of General Surgery, Gunma University Hospital, Gunma, Japan., Wu T; Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China., Wei F; China National Environmental Monitoring Center, Beijing, China., Dai H; Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China., Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Su J; Guangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China., Kim YH; Department of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea., Oh IJ; Lung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasuneup, Republic of Korea.; Department of Internal Medicine, Chonnam National Univerisity Medical School, Gwangju, Republic of Korea., Lee VHF; Department of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong., Chang GC; School of Medicine and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Internal Medicine, Division of Pulmonary Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Tsai YH; Department of Respiratory Therapy, Chang Gung University, Taoyuan, Taiwan.; Department of Pulmonary and Critical Care, Xiamen Chang Gung Hospital, Xiamen, China., Chen KY; Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan., Huang MS; Department of Internal Medicine, E-Da Cancer Hospital, I-Shou University and Kaohsiung Medical University, Kaohsiung, Taiwan., Su WC; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Chen YM; Department of Chest Medicine, Taipei Veterans General Hospital, and school of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Seow A; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Park JY; Lung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea., Kweon SS; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.; Jeonnam Regional Cancer Center, Chonnam National University, Hwasun, Republic of Korea., Chen KC; Department of Internal Medicine, Division of Pulmonary Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan., Gao YT; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China., Qian B; Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China., Wu C; Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Lu D; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China., Liu J; Genome Institute of Singapore, Agency of Science, Technology and Research, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Schwartz AG; Karmanos Cancer Institute, Detroit, MI, USA., Houlston R; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Spitz MR; Department of Medicine, Section of Epidemiology and Population Science, Institute for Clinical and Translational Research, Houston, TX, USA., Gorlov IP; Department of Medicine, Section of Epidemiology and Population Science, Institute for Clinical and Translational Research, Houston, TX, USA., Wu X; School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Yang P; Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA., Lam S; British Columbia Cancer Agency, Vancouver, BC, Canada., Tardon A; IUOPA, University of Oviedo and CIBERESP, Madrid, Spain., Chen C; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Bojesen SE; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Johansson M; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Risch A; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.; University of Salzburg and Cancer Cluster Salzburg, Salzburg, Austria., Bickeböller H; University Medical Center Goettingen, Goettingen, Germany., Ji BT; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Wichmann HE; Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University, Munich, Germany.; Helmholtz Center Munich, Institute of Epidemiology, Munich, Germany.; Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany., Christiani DC; Harvard TH Chan School of Public Health, Boston, MA, USA., Rennert G; Carmel Medical Center, Haifa, Israel., Arnold S; Markey Cancer Center, Lexington, KY, USA., Brennan P; International Agency for Research on Cancer (IARC/WHO), Lyon, France., McKay J; International Agency for Research on Cancer (IARC/WHO), Lyon, France., Field JK; Liverpool University, Liverpool, UK., Shete SS; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Liu G; Princess Margaret Cancer Center, Toronto, ON, Canada., Andrew A; Norris Cotton Cancer Center, Lebanon, NH, USA., Kiemeney LA; Radboud University Medical Center, Nijmegen, Netherlands., Zienolddiny-Narui S; National Institute of Occupational Health, Oslo, Norway., Grankvist K; Department of Medical Biosciences, Umeå University, Umeå, Sweden., Johansson M; Department of Radiation Sciences, Umeå University, Umeå, Sweden., Cox A; University of Sheffield, Sheffield, UK., Taylor F; University of Sheffield, Sheffield, UK., Yuan JM; UPMC Hillman Cancer Center and Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Lazarus P; Washington State University College of Pharmacy, Spokane, WA, USA., Schabath MB; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Aldrich MC; Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Jeon HS; Cancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea., Jiang SS; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan., Sung JS; Department of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea., Chen CH; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan., Hsiao CF; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan., Jung YJ; Department of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Guo H; Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Hu Z; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China., Burdett L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Rockville, MD, USA., Yeager M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Rockville, MD, USA., Hutchinson A; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Rockville, MD, USA., Hicks B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Rockville, MD, USA., Liu J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Rockville, MD, USA., Zhu B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Rockville, MD, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Wu W; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China., Wang J; Department of Biochemistry, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Centre for Genomic Sciences, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Li Y; Department of Human Genetics, Genome Institute of Singapore, Singapore, Singapore., Choi JE; Cancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea., Park KH; Department of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea., Sung SW; Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Liu L; Department of Oncology, Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan, China., Kang CH; Department of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Wang WC; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Xu J; School of Public Health, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Guan P; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China., Tan W; Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Yu CJ; Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan., Yang G; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA., Sihoe ADL; Gleneagles Hong Kong Hospital, Hong Kong, China., Chen Y; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Choi YY; Cancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea., Kim JS; Department of Internal Medicine, Division of Medical Oncology, College of Medicine, Korea University Guro Hospital, Seoul, Republic of Korea., Yoon HI; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Park IK; Department of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Xu P; Department of Oncology, Wuhan Iron and Steel (Group) Corporation Staff-Worker Hospital, Wuhan, China., He Q; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China., Wang CL; Department of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Hung HH; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan., Vermeulen RCH; Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands., Cheng I; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA., Wu J; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China., Lim WY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Tsai FY; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan., Chan JKC; Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China., Li J; Qujing Center for Diseases Control and Prevention, Qujing, China., Chen H; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China., Lin HC; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan., Jin L; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China., Liu J; Department of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China., Sawada N; Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan., Yamaji T; Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan., Wyatt K; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Rockville, MD, USA., Li SA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Rockville, MD, USA., Ma H; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China., Zhu M; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China., Wang Z; Department of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China., Cheng S; Department of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China., Li X; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China., Ren Y; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China., Chao A; Center for Global Health, National Cancer Institute, Bethesda, MD, USA., Iwasaki M; Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.; Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan., Zhu J; Shanghai Pulmonary Hospital, Shanghai, China., Jiang G; Shanghai Pulmonary Hospital, Shanghai, China., Fei K; Shanghai Pulmonary Hospital, Shanghai, China., Wu G; China National Environmental Monitoring Center, Beijing, China., Chen CY; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan., Chen CJ; Genomic Research Center, Academia Sinica, Taipei, Taiwan., Yang PC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Yu J; Department of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China., Stevens VL; Laboratory Services, American Cancer Society, Atlanta, GA, USA., Fraumeni JF Jr; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Chatterjee N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Gorlova OY; Department of Medicine, Section of Epidemiology and Population Science, Institute for Clinical and Translational Research, Houston, TX, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Hsiung CA; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan., Amos CI; Department of Medicine, Section of Epidemiology and Population Science, Institute for Clinical and Translational Research, Houston, TX, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Shen H; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Rothman N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Kohno T; Division of Genome Biology, National Cancer Research Institute, Tokyo, Japan., Lan Q; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. qingl@mail.nih.gov.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 May 26; Vol. 14 (1), pp. 3043. Date of Electronic Publication: 2023 May 26.
DOI: 10.1038/s41467-023-38196-z
Abstrakt: Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P interaction  = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.
(© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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