Selective Hydroxylation of C(sp 3 )-H Bonds in Steroids.

Autor: Abas H; Cancer Research Horizons, Babraham Research Campus, Cambridge, CB22 3AT, UK., Blencowe P; Cancer Research Horizons, Babraham Research Campus, Cambridge, CB22 3AT, UK., Brookfield JL; Cancer Research Horizons, Babraham Research Campus, Cambridge, CB22 3AT, UK., Harwood LA; Cancer Research Horizons, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Aug 04; Vol. 29 (44), pp. e202301066. Date of Electronic Publication: 2023 Jul 12.
DOI: 10.1002/chem.202301066
Abstrakt: Steroids are highly prevalent structures in small-molecule therapeutics, with the level of oxidation being key to their biological activity and physicochemical properties. These C(sp 3 )-rich tetracycles contain many stereocentres, which are important for creating specific vectors and protein binding orientations. Therefore, the ability to hydroxylate steroids with a high degree of regio-, chemo- and stereoselectivity is essential for researchers working in this field. This review will cover three main methods for the hydroxylation of steroidal C(sp 3 )-H bonds: biocatalysis, metal-catalysed C-H hydroxylation and organic oxidants, such as dioxiranes and oxaziridines.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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