Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine.

Autor: Ibancovichi JA; Departamento de Anestesiología y Analgesia, Facultad de Medicina Veterinaria, Universidad Autónoma del Estado de México, UAEM, Toluca 50000, Mexico., Chávez-Monteagudo JR; Departamento de Ciencias Pecuarias, Facultad de Estudios Superiores Cuautitlán, Hospital de Pequeñas Especies, Universidad Nacional Autónoma de México, UNAM, Cuautitlán Izcalli 54740, Mexico., Sánchez-Aparicio P; Departamento de Farmacología, Facultad de Medicina Veterinaria, Universidad Autónoma del Estado de México, UAEM, Toluca 50000, Mexico., De Paz-Campos MA; Departamento de Ciencias Biológicas, Facultad de Estudios Superiores Cuautitlán, Hospital de Pequeñas Especies, Universidad Nacional Autónoma de México, UNAM, Cuautitlán Izcalli 54740, Mexico.
Jazyk: angličtina
Zdroj: Veterinary sciences [Vet Sci] 2023 Apr 24; Vol. 10 (5). Date of Electronic Publication: 2023 Apr 24.
DOI: 10.3390/vetsci10050310
Abstrakt: The impacts of morphine and dexmedetomidine on the MAC of isoflurane were studied in rats constantly medicated with the cannabinoid WIN 55,212-2.
Methods: Prior to the administration of morphine, the MAC was measured in both untreated rats (MAC (ISO) ) and those treated with a cannabinoid (MAC (ISO + CANN) ). The effects of morphine (MAC (ISO + MOR) ) and dexmedetomidine (MAC (ISO + DEX) ) on untreated rats and rats treated for 21 days with the cannabinoids (MAC (ISO + CANN + MOR) ) and (MAC (ISO + CANN + DEX ) were also studied.
Results: MAC (ISO) was 1.32 ± 0.06, and MAC (ISO + CANN) was 1.69 ± 0.09. MAC (ISO + MOR) was 0.97 ± 0.02 (26% less than MAC (ISO) ). MAC (ISO + CANN + MOR) was 1.55 ± 0.08 (8% less than MAC (ISO + CANN) ), MAC (ISO + DEX) was 0.68 ± 0.10 (48% less than MAC (ISO) ), and MAC (ISO + CANN + DEX) was 0.67 ± 0.08 (60% less than MAC (ISO + CANN) ).
Conclusions: Medication with a cannabinoid for 21 days augmented the MAC of isoflurane. The sparing effect of morphine on isoflurane is lower in rats constantly medicated with a cannabinoid. The sparing effect of dexmedetomidine on the minimum alveolar concentration of isoflurane is greater in rats repeatedly medicated with a cannabinoid.
Databáze: MEDLINE
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