Label-Free Chemically and Molecularly Selective Magnetic Resonance Imaging.

Autor:	Wu T; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States., Liu C; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21205, United States., Thamizhchelvan AM; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States., Fleischer C; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States., Peng X; Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, China., Liu G; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21205, United States.; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States., Mao H; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Jazyk:	angličtina
Zdroj:	Chemical & biomedical imaging [Chem Biomed Imaging] 2023 Apr 12; Vol. 1 (2), pp. 121-139. Date of Electronic Publication: 2023 Apr 12 (Print Publication: 2023).
DOI:	10.1021/cbmi.3c00019
Abstrakt:	Biomedical imaging, especially molecular imaging, has been a driving force in scientific discovery, technological innovation, and precision medicine in the past two decades. While substantial advances and discoveries in chemical biology have been made to develop molecular imaging probes and tracers, translating these exogenous agents to clinical application in precision medicine is a major challenge. Among the clinically accepted imaging modalities, magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) exemplify the most effective and robust biomedical imaging tools. Both MRI and MRS enable a broad range of chemical, biological and clinical applications from determining molecular structures in biochemical analysis to imaging diagnosis and characterization of many diseases and image-guided interventions. Using chemical, biological, and nuclear magnetic resonance properties of specific endogenous metabolites and native MRI contrast-enhancing biomolecules, label-free molecular and cellular imaging with MRI can be achieved in biomedical research and clinical management of patients with various diseases. This review article outlines the chemical and biological bases of several label-free chemically and molecularly selective MRI and MRS methods that have been applied in imaging biomarker discovery, preclinical investigation, and image-guided clinical management. Examples are provided to demonstrate strategies for using endogenous probes to report the molecular, metabolic, physiological, and functional events and processes in living systems, including patients. Future perspectives on label-free molecular MRI and its challenges as well as potential solutions, including the use of rational design and engineered approaches to develop chemical and biological imaging probes to facilitate or combine with label-free molecular MRI, are discussed. Competing Interests: The authors declare no competing financial interest. (© 2023 The Authors. Co-published by Nanjing University and American Chemical Society.)
Databáze:	MEDLINE
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