| Autor: |
Nga TT; Faculty of Basic Sciences, University of Transport and Communications, Hanoi, Vietnam., Thi Hoan L; Faculty of Basic Sciences, University of Transport and Communications, Hanoi, Vietnam., Anh BTM; Faculty of Basic Sciences, University of Transport and Communications, Hanoi, Vietnam., Mai NT; Faculty of Basic Sciences, University of Transport and Communications, Hanoi, Vietnam., Huong PTT; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Nhiem NX; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Kiem PV; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam., Tai BH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam. |
| Abstrakt: |
A phytochemical investigation of the methanolic extract of aerial parts of the Acanthus ilicifolius led to the isolation of two new lignan glycosides, acaniliciosides A and B ( 1 and 2 ), together with ten known compounds ( 3 - 12 ). The structures of isolated compounds were elucidated based on HR-ESI-MS, 1D and 2D NMR spectroscopic data. The absolute configurations of two new compounds were established by CD spectra. With the exception of compound 12 , other compounds inhibited NO production in LPS activated RAW264.7 cells with IC 50 values of 2.14-28.18 µM, as potent as that of the positive control of N G -monomethyl-L-arginine acetate (L-NMMA, IC 50 of 32.50 µM). In addition, compounds 5 - 8 showed cytotoxic effects against SK-LU-1 and HepG2 cell lines with the IC 50 values ranging from 16.48 to 76.40 μM compared to the positive control (ellipticine) with the IC 50 values ranging from 1.23 to 1.46 μM. |
