Neuropeptides Modulate Feeding via the Dopamine Reward Pathway.

Autor: Jin R; Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.; Department of Clinical Medicine, Medical College, Qingdao University, Qingdao, China., Sun S; Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.; Department of Clinical Medicine, Medical College, Qingdao University, Qingdao, China., Hu Y; Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.; Department of Clinical Medicine, Medical College, Qingdao University, Qingdao, China., Zhang H; Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.; Department of Clinical Medicine, Medical College, Qingdao University, Qingdao, China., Sun X; Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China. xr.sun@qdu.edu.cn.
Jazyk: angličtina
Zdroj: Neurochemical research [Neurochem Res] 2023 Sep; Vol. 48 (9), pp. 2622-2643. Date of Electronic Publication: 2023 May 26.
DOI: 10.1007/s11064-023-03954-4
Abstrakt: Dopamine (DA) is a catecholamine neurotransmitter widely distributed in the central nervous system. It participates in various physiological functions, such as feeding, anxiety, fear, sleeping and arousal. The regulation of feeding is exceptionally complex, involving energy homeostasis and reward motivation. The reward system comprises the ventral tegmental area (VTA), nucleus accumbens (NAc), hypothalamus, and limbic system. This paper illustrates the detailed mechanisms of eight typical orexigenic and anorexic neuropeptides that regulate food intake through the reward system. According to recent literature, neuropeptides released from the hypothalamus and other brain regions regulate reward feeding predominantly through dopaminergic neurons projecting from the VTA to the NAc. In addition, their effect on the dopaminergic system is mediated by the prefrontal cortex, paraventricular thalamus, laterodorsal tegmental area, amygdala, and complex neural circuits. Research on neuropeptides involved in reward feeding can help identify more targets to treat diseases with metabolic disorders, such as obesity.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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