| Autor: |
Himiniuc LM; Department of Obstetrics and Gynecology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Socolov R; Department of Obstetrics and Gynecology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Nica I; Department of Odontology-Periodontology, Fixed Prosthesis, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Agop M; Department of Physics, 'Gheorghe Asachi' Technical University of Iasi, 700050 Iasi, Romania.; Romanian Scientists Academy, 050094 Bucharest, Romania., Volovat C; Department of Medical Oncology-Radiotherapy, 'Grigore T. Popa' University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania., Ochiuz L; Faculty of Pharmacy, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Vasincu D; Department of Biophysics, Faculty of Dental Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Rotundu AM; Faculty of Physics, 'Alexandru Ioan Cuza' University of Iasi, 700506 Iasi, Romania., Rosu IA; Faculty of Physics, 'Alexandru Ioan Cuza' University of Iasi, 700506 Iasi, Romania., Ghizdovat V; Department of Biophysics and Medical Physics, 'Grigore T. Popa' University of Medicine and Pharmacy, Iasi 700115, Romania., Volovat SR; Department of Medical Oncology-Radiotherapy, 'Grigore T. Popa' University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania. |
| Abstrakt: |
Two formulations based on diclofenac sodium salt encapsulated into a chitosan hydrogel were designed and prepared, and their drug release was investigated by combining in vitro results with mathematical modeling. To understand how the pattern of drug encapsulation impacted its release, the formulations were supramolecularly and morphologically characterized by scanning electron microscopy and polarized light microscopy, respectively. The mechanism of diclofenac release was assessed by using a mathematical model based on the multifractal theory of motion. Various drug-delivery mechanisms, such as Fickian- and non-Fickian-type diffusion, were shown to be fundamental mechanisms. More precisely, in a case of multifractal one-dimensional drug diffusion in a controlled-release polymer-drug system (i.e., in the form of a plane with a certain thickness), a solution that allowed the model's validation through the obtained experimental data was established. The present research reveals possible new perspectives, for example in the prevention of intrauterine adhesions occurring through endometrial inflammation and other pathologies with an inflammatory mechanism background, such as periodontal diseases, and also therapeutic potential beyond the anti-inflammatory action of diclofenac as an anticancer agent, with a role in cell cycle regulation and apoptosis, using this type of drug-delivery system. |
