Renal Transplantation in the Elderly: Are They All the Same? A Multicenter, Comorbidity-Based Study.

Autor:	Fragale G; Nefrología y Trasplante renal, Hospital Universitario Austral, Buenos Aires, Argentina., Laham G; Sección Nefrología, Centro de Educación Médica e Investigaciones Clínicas, 'Norberto Quirno', Buenos Aires, Argentina., Raffaele P; Unidad renal, Fundación Favaloro, Buenos Aires, Argentina., Fortunato M; Unidad renal, Fundación Favaloro, Buenos Aires, Argentina., Villamil S; Trasplante renal, Hospital Italiano, Buenos Aires, Argentina., Giordani MC; Trasplante renal, Hospital Italiano, Buenos Aires, Argentina., Taylor M; Centro Regional de Ablación e Implante Sur, Hospital San Martín, La Plata, Buenos Aires, Argentina., Ciappa J; Centro Regional de Ablación e Implante Sur, Hospital San Martín, La Plata, Buenos Aires, Argentina., Rodriguez M; Nefrología y Trasplante renal, Clínica Vélez Sarsfield, Córdoba, Argentina., Maldonado R; Nefrología y Trasplante renal, Clínica Vélez Sarsfield, Córdoba, Argentina., Trimarchi H; Servicio de Nefrología, Hospital Británico, Buenos Aires, Argentina., Pomeranz V; Servicio de Nefrología, Hospital Británico, Buenos Aires, Argentina., Ellena V; Servicio de Nefrología, Hospital Privado Universitario de Córdoba, Cordoba, Argentina., De La Fuente J; Servicio de Nefrología, Hospital Privado Universitario de Córdoba, Cordoba, Argentina., Bisigniano L; Dirección Científico Técnica, Instituto Nacional Central Único Coordinador de Ablación e Implante (INCUCAI), Buenos Aires, Argentina., Antik A; Dirección Científico Técnica, Instituto Nacional Central Único Coordinador de Ablación e Implante (INCUCAI), Buenos Aires, Argentina., Soler Pujol G; Sección Nefrología, Centro de Educación Médica e Investigaciones Clínicas, 'Norberto Quirno', Buenos Aires, Argentina.
Jazyk:	angličtina
Zdroj:	Nephron [Nephron] 2023; Vol. 147 (9), pp. 550-559. Date of Electronic Publication: 2023 May 25.
DOI:	10.1159/000531178
Abstrakt:	Introduction: The age for kidney transplantation (KT) is no longer a limitation and several studies have shown benefits in the survival of elderly patients. The aim of this study was to examine the relationship of the baseline Charlson comorbidity index (CCI) score to morbidity and mortality after transplantation. Methods: In this multicentric observational retrospective cohort study, we included patients older than 60 years admitted on the waiting list (WL) for deceased donor KT from January 01, 2006, to December 31, 2016. The CCI score was calculated for each patient at inclusion on the WL. Results: Data for analysis were available of 387 patients. The patients were divided in tertiles of CCI: group 1 (CCI: 1-2) n = 117, group 2 (CCI: 3-4) n = 158, and group 3 (CCI: ≥5) n = 112. Patient survival was significantly different between CCI groups at 1, 3, and 5 years, respectively: 90%, 88%, and 84% for group 1, 88%, 80%, and 72% for group 2, and 87%, 75%, and 63% for group 3 (p < 0.0001). Variables associated with mortality were CCI score (p < 0.0001), HLA mismatch (p = 0.014), length of hospital stay (p < 0.0001), surgical complications (p = 0.048). Conclusion: Individualized strategies to modify these variables may improve patient's morbidity and mortality after KT. (© 2023 S. Karger AG, Basel.)
Databáze:	MEDLINE
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