Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort.

Autor: Bujosa F; Department of Endocrinology and Nutrition, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, Hospital Clínic of Barcelona, 08036 Barcelona, Spain., Herreras Z; Consorcio de Atención Primaria del Eixample (CAPSE), Grup Transversal de Recerca en Atenció Primària, IDIBAPS, 08036 Barcelona, Spain., Catalán M; Consorcio de Atención Primaria del Eixample (CAPSE), Grup Transversal de Recerca en Atenció Primària, IDIBAPS, 08036 Barcelona, Spain., Pinyol M; Consorcio de Atención Primaria del Eixample (CAPSE), Grup Transversal de Recerca en Atenció Primària, IDIBAPS, 08036 Barcelona, Spain., Lamuela-Raventos RM; Department of Nutrition, Food Science and Gastronomy, XIA, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain; INSA-UB, Nutrition and Food Safety Research Institute, University of Barcelona, 08028 Barcelona, Spain; Biomedical Network Research Centre on Obesity and Nutrition Physiopathology (CIBEROBN) Instituto de Salud Carlos III, 28029 Madrid, Spain., Martínez-Huélamo M; Department of Nutrition, Food Science and Gastronomy, XIA, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain; INSA-UB, Nutrition and Food Safety Research Institute, University of Barcelona, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain., Gilabert R; Vascular Unit, Centre de Diagnòstic per l'Imatge, IDIBAPS, Hospital Clínic, 08036 Barcelona, Spain., Jiménez A; Department of Endocrinology and Nutrition, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, Hospital Clínic of Barcelona, 08036 Barcelona, Spain; Biomedical Network Research Centre on Obesity and Nutrition Physiopathology (CIBEROBN) Instituto de Salud Carlos III, 28029 Madrid, Spain., Ortega E; Department of Endocrinology and Nutrition, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, Hospital Clínic of Barcelona, 08036 Barcelona, Spain; Biomedical Network Research Centre on Obesity and Nutrition Physiopathology (CIBEROBN) Instituto de Salud Carlos III, 28029 Madrid, Spain., Chiva-Blanch G; Department of Endocrinology and Nutrition, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, Hospital Clínic of Barcelona, 08036 Barcelona, Spain; Biomedical Network Research Centre on Obesity and Nutrition Physiopathology (CIBEROBN) Instituto de Salud Carlos III, 28029 Madrid, Spain; Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain. Electronic address: gchivab@uoc.edu.
Jazyk: angličtina
Zdroj: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2023 Jul; Vol. 42 (7), pp. 1168-1174. Date of Electronic Publication: 2023 May 13.
DOI: 10.1016/j.clnu.2023.05.005
Abstrakt: Background and Aims: Atherosclerosis is the major risk factor for cardiovascular disease (CVD), the first cause of death worldwide. Chronic low-grade inflammation and a sustained oxidative milieu are causatively related to atherosclerosis onset and progression, and therefore, dietary patterns rich in bioactive compounds with anti-inflammatory and antioxidant activities might likely contribute to revert or slowing the progression of atherosclerosis. The aim of this study is to analyse the association between fruit and vegetables intake, quantitatively measured through carotene plasma concentrations, and atherosclerotic burden, as a surrogate biomarker of CVD, in free-living subjects from the DIABIMCAP cohort study.
Methods: The 204 participants of the DIABIMCAP Study cohort (Carotid Atherosclerosis in Newly Diagnosed Type 2 Diabetic Individuals, ClinicalTrials.gov Identifier: NCT01898572), were included in this cross-sectional study. Total, α-, and β-carotenes were quantified by HPLC-MS/MS. Lipoprotein analysis in serum was performed by 2D- 1H NMR- DOSY, and atherosclerosis and intima media thickness (IMT) were measured through standardized bilateral carotid artery ultrasound imaging.
Results: Subjects with atherosclerosis (n = 134) had lower levels of large HDL particles than subjects without atherosclerosis. Positive associations were found between α-carotene and both large and medium HDL particles, and inverse associations were found between β- and total carotene, and VLDL and its medium/small particles. Subjects with atherosclerosis presented significantly lower plasma concentrations of total carotene compared with subjects without atherosclerosis. Plasma concentrations of carotene decreased as the number of atherosclerotic plaques increased, although after multivariate adjustment, the inverse association between β- and total carotene with plaque burden remained significant only in women.
Conclusions: A diet rich in fruit and vegetables results in higher plasmatic carotene concentrations, which are associated with a lesser atherosclerotic plaque burden.
Competing Interests: Conflicts of interest The authors declare no conflicts of interest.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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